PMID- 23566619
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20211203
IS  - 2213-3941 (Electronic)
IS  - 0003-4266 (Linking)
VI  - 74
IP  - 2
DP  - 2013 May
TI  - The role of the mTOR pathway during liver regeneration and tumorigenesis.
PG  - 121-2
LID - S0003-4266(13)00030-9 [pii]
LID - 10.1016/j.ando.2013.03.003 [doi]
AB  - It is established that overnutrition is a risk factor for hepatocellular 
      carcinoma. Il has been proposed that hepatic steatosis leads to a subinflammatory 
      response and to the production of mitogenic cytokines. Our team is focused on the 
      role of mammalian Target of Rapamycin (mTOR) in two pathophysiological conditions 
      that modulate liver growth: liver regeneration after partial hepatectomy, and 
      steatosis-associated tumorigenesis. Target kinases of mTOR seem more specifically 
      involved in these processes: while S6K1 contributes to liver regeneration 
      following hepatectomy, Akt2 is implicated in steatosis-associated tumorigenesis. 
      In addition, recent data indicate that the transcription factor PPARgamma, through an 
      activation of glycolytic enzymes, could promote liver steatosis, hypertrophy and 
      hyperplasia.
CI  - Copyright (c) 2013 Elsevier Masson SAS. All rights reserved.
FAU - Panasyuk, Ganna
AU  - Panasyuk G
AD  - Inserm U845, Paris Descartes University, 96, rue Didot, 75014 Paris, France.
FAU - Patitucci, Cecilia
AU  - Patitucci C
FAU - Espeillac, Catherine
AU  - Espeillac C
FAU - Pende, Mario
AU  - Pende M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130406
PL  - France
TA  - Ann Endocrinol (Paris)
JT  - Annales d'endocrinologie
JID - 0116744
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Carcinogenesis/genetics
MH  - Carcinoma, Hepatocellular/*etiology/genetics/metabolism
MH  - Fatty Liver/complications/pathology
MH  - Hepatectomy/adverse effects/rehabilitation
MH  - Humans
MH  - Liver Neoplasms/*etiology/genetics/metabolism
MH  - Liver Regeneration/genetics/*physiology
MH  - Signal Transduction/genetics/physiology
MH  - TOR Serine-Threonine Kinases/genetics/metabolism/*physiology
EDAT- 2013/04/10 06:00
MHDA- 2014/01/23 06:00
CRDT- 2013/04/10 06:00
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - S0003-4266(13)00030-9 [pii]
AID - 10.1016/j.ando.2013.03.003 [doi]
PST - ppublish
SO  - Ann Endocrinol (Paris). 2013 May;74(2):121-2. doi: 10.1016/j.ando.2013.03.003. 
      Epub 2013 Apr 6.