PMID- 23566939
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20211021
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Print)
IS  - 0161-5890 (Linking)
VI  - 55
IP  - 3-4
DP  - 2013 Oct
TI  - Structural basis for the differential classification of HLA-A*6802 and HLA-A*6801 
      into the A2 and A3 supertypes.
PG  - 381-92
LID - S0161-5890(13)00110-7 [pii]
LID - 10.1016/j.molimm.2013.03.015 [doi]
AB  - High polymorphism is one of the most important features of human leukocyte 
      antigen (HLA) alleles, which were initially classified by serotyping but have 
      recently been re-grouped into supertypes according to their peptide presentation 
      properties. Two relatively prevalent HLA alleles HLA-A*6801 and HLA-A*6802, are 
      classified into the same serotype HLA-A68. However, based on their distinct 
      peptide-binding characteristics, HLA-A*6801 is grouped into A3 supertype, whereas 
      HLA-A*6802 belongs to A2 supertype, similar to HLA-A*0201. Thusfar, the 
      structural basis of the different supertype definitions of these 
      serotyping-identical HLA alleles remains largely unknown. Herein, we determined 
      the structures of HLA-A*6801 and HLA-A*6802 presenting three typical A3 and A2 
      supertype-restricted peptides, respectively. The binding capabilities of these 
      peptides to HLA-A*6801, HLA-A*6802, and HLA-A*0201 were analyzed. These data 
      indicate that the similar conformations of the residues within the F pocket 
      contribute to close-related peptide binding features of HLA-A*6802 and 
      HLA-A*0201. However, the overall structure and the peptide conformation of 
      HLA-A*6802 are more similar to HLA-A*6801 rather than HLA-A*0201 which 
      illuminates the similar serotype grouping of HLA-A*6802 and HLA-A*6801. Our 
      findings are helpful for understanding the divergent peptide presentation and 
      virus-specific CTL responses impacted by MHC micropolymorphisms and also 
      elucidate the molecular basis of HLA supertype definitions.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Niu, Ling
AU  - Niu L
AD  - CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of 
      Microbiology, Chinese Academy of Sciences, Beijing, China.
FAU - Cheng, Hao
AU  - Cheng H
FAU - Zhang, Shihong
AU  - Zhang S
FAU - Tan, Shuguang
AU  - Tan S
FAU - Zhang, Yudan
AU  - Zhang Y
FAU - Qi, Jianxun
AU  - Qi J
FAU - Liu, Jun
AU  - Liu J
FAU - Gao, George F
AU  - Gao GF
LA  - eng
SI  - PDB/4HWZ
SI  - PDB/4HX1
SI  - PDB/4I48
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130406
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*02:01 antigen)
RN  - 0 (HLA-A*68 antigen)
RN  - 0 (HLA-A2 Antigen)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Antigen Presentation/genetics/immunology
MH  - Crystallography, X-Ray
MH  - HLA-A Antigens/*chemistry/*classification/genetics
MH  - HLA-A2 Antigen/chemistry/classification/genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Sequence Homology, Amino Acid
MH  - Serotyping
PMC - PMC7112617
EDAT- 2013/04/10 06:00
MHDA- 2013/07/16 06:00
PMCR- 2013/04/06
CRDT- 2013/04/10 06:00
PHST- 2013/02/06 00:00 [received]
PHST- 2013/03/15 00:00 [accepted]
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
PHST- 2013/04/06 00:00 [pmc-release]
AID - S0161-5890(13)00110-7 [pii]
AID - 10.1016/j.molimm.2013.03.015 [doi]
PST - ppublish
SO  - Mol Immunol. 2013 Oct;55(3-4):381-92. doi: 10.1016/j.molimm.2013.03.015. Epub 
      2013 Apr 6.