PMID- 23567093
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20161125
IS  - 1094-6950 (Print)
IS  - 1094-6950 (Linking)
VI  - 17
IP  - 1
DP  - 2014 Jan-Mar
TI  - Measuring apparent trabecular structure with pQCT: a comparison with HR-pQCT.
PG  - 47-53
LID - S1094-6950(13)00039-5 [pii]
LID - 10.1016/j.jocd.2013.03.002 [doi]
AB  - We evaluated how comparable peripheral quantitative computed tomography (pQCT) 
      measurements of cortical thickness, density, and apparent trabecular structure at 
      the ultradistal tibia were with those measured with high-resolution pQCT 
      (HR-pQCT). We also examined whether the accuracy of the pQCT-based trabecular and 
      cortical measurements improved with reductions in slice thickness from the 
      standard 2.2mm to 1.1 and 0.6mm. We immersed 15 dry tibia specimens in saline in 
      a sealed cylinder and scanned 22.5mm from the distal tibia plateau using pQCT and 
      HR-pQCT. pQCT underestimated cortical thickness by Stratec (CThStratec) and 
      trabecular spacing (Tb.Sp) by 21.4% and 72.9%, whereas bone volume to total 
      volume (BV/TV) and cortical density (CDen) were overestimated by 265.8% and 
      13.1%, respectively. Measurements of trabecular volumetric bone mineral density, 
      trabecular area, total area, cortical thickness by custom software were 
      comparable, but for CThStratec, Tb.Sp, BV/TV, and CDen, the differences between 
      imaging devices varied with magnitude of the estimate. We recommend that 
      researchers or clinicians interested in using pQCT to measure apparent trabecular 
      structure or cortical thickness at the epiphyses, or in comparing findings from 
      different devices, be aware of the differences between HR-pQCT and pQCT.
CI  - Copyright (c) 2014 The International Society for Clinical Densitometry. Published 
      by Elsevier Inc. All rights reserved.
FAU - Lala, Deena
AU  - Lala D
AD  - Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada; Toronto 
      Rehabilitation Institute-University Health Network, Lyndhurst Centre, Toronto, 
      ON, Canada.
FAU - Cheung, Angela M
AU  - Cheung AM
AD  - Department of Medicine and Medical Imaging, University of Toronto, Toronto, ON, 
      Canada; University Health Network, Toronto, ON, Canada.
FAU - Lynch, Cheryl L
AU  - Lynch CL
AD  - Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada; Toronto 
      Rehabilitation Institute-University Health Network, Lyndhurst Centre, Toronto, 
      ON, Canada.
FAU - Inglis, Dean
AU  - Inglis D
AD  - Department of Civil Engineering, McMaster University, Hamilton, ON, Canada.
FAU - Gordon, Chris
AU  - Gordon C
AD  - Department of Radiology, McMaster University, Hamilton, ON, Canada.
FAU - Tomlinson, George
AU  - Tomlinson G
AD  - Department of Medicine and Medical Imaging, University of Toronto, Toronto, ON, 
      Canada; University Health Network, Toronto, ON, Canada; Dalla Lana School of 
      Public Health, University of Toronto, Toronto, ON, Canada.
FAU - Giangregorio, Lora
AU  - Giangregorio L
AD  - Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada; Toronto 
      Rehabilitation Institute-University Health Network, Lyndhurst Centre, Toronto, 
      ON, Canada. Electronic address: lora.giangregorio@uwaterloo.ca.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130406
PL  - United States
TA  - J Clin Densitom
JT  - Journal of clinical densitometry : the official journal of the International 
      Society for Clinical Densitometry
JID - 9808212
SB  - IM
MH  - Anatomy, Cross-Sectional
MH  - Body Weights and Measures
MH  - *Bone Density
MH  - Cadaver
MH  - Humans
MH  - Reproducibility of Results
MH  - Tibia/*diagnostic imaging/*pathology
MH  - *Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Accuracy
OT  - bone density
OT  - bone geometry
OT  - bone structure
OT  - peripheral quantitative computed tomography
EDAT- 2013/04/10 06:00
MHDA- 2014/04/25 06:00
CRDT- 2013/04/10 06:00
PHST- 2013/01/30 00:00 [received]
PHST- 2013/03/01 00:00 [revised]
PHST- 2013/03/01 00:00 [accepted]
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
AID - S1094-6950(13)00039-5 [pii]
AID - 10.1016/j.jocd.2013.03.002 [doi]
PST - ppublish
SO  - J Clin Densitom. 2014 Jan-Mar;17(1):47-53. doi: 10.1016/j.jocd.2013.03.002. Epub 
      2013 Apr 6.