PMID- 23567147
OWN - NLM
STAT- MEDLINE
DCOM- 20131211
LR  - 20240229
IS  - 1569-8041 (Electronic)
IS  - 0923-7534 (Print)
IS  - 0923-7534 (Linking)
VI  - 24
IP  - 7
DP  - 2013 Jul
TI  - Prevalence of iron deficiency across different tumors and its association with 
      poor performance status, disease status and anemia.
PG  - 1886-1892
LID - S0923-7534(19)36660-8 [pii]
LID - 10.1093/annonc/mdt118 [doi]
AB  - BACKGROUND: Only limited data on the prevalence of iron deficiency (ID) and its 
      correlation with clinical parameters are available in cancer. ID frequently 
      contributes to the pathogenesis of anemia in patients with cancer and may lead to 
      several symptoms such as impaired physical function, weakness and fatigue. 
      PATIENTS AND METHODS: Parameters of iron status and clinical parameters were 
      evaluated in 1528 patients with cancer who presented consecutively within a 
      four-month period at our center. One thousand fifty-three patients had solid 
      tumors and 475 hematological malignancies. RESULTS: ID [transferrin saturation 
      (TSAT) < 20%] was noted in 645 (42.6%) of the 1513 patients with TSAT tests 
      available and 500 (33.0%) were anemic. ID rates were highest in pancreatic 
      (63.2%), colorectal (51.9%) and lung cancers (50.7%). Of the 409 iron-deficient 
      patients in whom serum ferritin levels were available additionally to TSAT, 335 
      (81.9%) presented with functional ID (FID) (TSAT < 20%, serum ferritin >/=30 ng/ml) 
      and 74 (18.1%) with absolute ID. In patients with solid tumors, prevalence of ID 
      correlated with cancer stage at diagnosis (P = 0.001), disease status (P = 0.001) 
      and ECOG performance status (P = 0.005). CONCLUSIONS: ID was frequently noted in 
      cancer and was associated with advanced disease, close proximity to cancer 
      therapy, and poor performance status in patients with solid tumors.
FAU - Ludwig, H
AU  - Ludwig H
AD  - Department of Medicine I, Center for Oncology, Haematology and Palliative Care, 
      Wilhelminenspital, Vienna. Electronic address: heinz.ludwig@wienkav.at.
FAU - Muldur, E
AU  - Muldur E
AD  - Department of Medicine I, Center for Oncology, Haematology and Palliative Care, 
      Wilhelminenspital, Vienna.
FAU - Endler, G
AU  - Endler G
AD  - Central Laboratory, Wilhelminenspital, Vienna, Austria.
FAU - Hubl, W
AU  - Hubl W
AD  - Central Laboratory, Wilhelminenspital, Vienna, Austria.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130407
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical 
      Oncology
JID - 9007735
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anemia, Iron-Deficiency/*epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*complications/epidemiology/therapy
MH  - Prevalence
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC3690908
OTO - NOTNLM
OT  - absolute iron deficiency
OT  - cancer-related anemia
OT  - chemotherapy-induced anemia
OT  - functional iron deficiency
OT  - iron deficiency
OT  - iron deficiency anemia
EDAT- 2013/04/10 06:00
MHDA- 2013/12/16 06:00
PMCR- 2013/04/07
CRDT- 2013/04/10 06:00
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2013/04/07 00:00 [pmc-release]
AID - S0923-7534(19)36660-8 [pii]
AID - mdt118 [pii]
AID - 10.1093/annonc/mdt118 [doi]
PST - ppublish
SO  - Ann Oncol. 2013 Jul;24(7):1886-1892. doi: 10.1093/annonc/mdt118. Epub 2013 Apr 7.