PMID- 23567599
OWN - NLM
STAT- MEDLINE
DCOM- 20131219
LR  - 20191027
IS  - 1809-452X (Electronic)
IS  - 1516-4446 (Linking)
VI  - 35
IP  - 1
DP  - 2013 Mar
TI  - The Val66Met polymorphism at the BDNF gene does not influence Wisconsin Card 
      Sorting Test results in children and adolescents with bipolar disorder.
PG  - 44-50
LID - S1516-44462013000100008 [pii]
AB  - OBJECTIVES: To assess the role of the Val66Met polymorphism at the brain-derived 
      neurotrophic factor (BDNF) gene on the performance of children and adolescents 
      with bipolar disorder [juvenile bipolar disorder (JBD)] on the Wisconsin Card 
      Sorting Test (WCST). METHODS: Children and adolescents were assessed by the 
      K-SADS-PL and a clinical evaluation for BD and comorbid conditions. Manic and 
      depressive symptoms were assessed with the Young Mania Rating Scale and the 
      Children Depression Rating Scale - Reviewed. The Val66Met polymorphism at the 
      BDNF was genotyped from a blood sample. Patients' IQ and executive functions were 
      assessed by a standard cognitive flexibility test (WCST). RESULTS: Fifty-three 
      subjects were included in the study. No significant difference was observed 
      between the Val/Val and Val/Met+Met/Met groups on any WCST scores in the MANCOVA 
      (F48,5 = .76; p = .59; Perseverative Errors, p = .66; Nonperseverative Errors, p 
      = .58; Categories Completed, p = .34; Attempts to Reach First Category, p=.64; 
      and Percentage of Conceptual Level Responses, p = .99). CONCLUSIONS: Our findings 
      from this sample of children and adolescents with BD do not replicate results 
      from studies of adults and suggest the existence of differences in the 
      neurobiology of this disorder across the life cycle. Investigations of larger 
      samples are necessary to confirm these data.
FAU - Zeni, Cristian Patrick
AU  - Zeni CP
AD  - Division of Child and Adolescent Psychiatry, Hospital de Clinicas de Porto 
      Alegre, Universidade Federal do Rio Grande do Sul, Brazil.
FAU - Tramontina, Silza
AU  - Tramontina S
FAU - Zeni, Thamis Aline
AU  - Zeni TA
FAU - Coelho, Roberta
AU  - Coelho R
FAU - Pheula, Gabriel
AU  - Pheula G
FAU - Bernardi, Julio
AU  - Bernardi J
FAU - Maldaner, Ursula
AU  - Maldaner U
FAU - Silva, Talita Lopes
AU  - Silva TL
FAU - Salatino-Oliveira, Angelica
AU  - Salatino-Oliveira A
FAU - Hutz, Mara
AU  - Hutz M
FAU - Rohde, Luis Augusto
AU  - Rohde LA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz J Psychiatry
JT  - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
JID - 100895975
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Analysis of Variance
MH  - Bipolar Disorder/diagnosis/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Intelligence Tests
MH  - Male
MH  - Neuropsychological Tests
MH  - Polymorphism, Genetic/*genetics
MH  - Statistics, Nonparametric
EDAT- 2013/04/10 06:00
MHDA- 2013/12/20 06:00
CRDT- 2013/04/10 06:00
PHST- 2011/10/11 00:00 [received]
PHST- 2012/02/18 00:00 [accepted]
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2013/12/20 06:00 [medline]
AID - S1516-44462013000100008 [pii]
AID - 10.1016/j.rbp.2012.02.007 [doi]
PST - ppublish
SO  - Braz J Psychiatry. 2013 Mar;35(1):44-50. doi: 10.1016/j.rbp.2012.02.007.