PMID- 23567603
OWN - NLM
STAT- MEDLINE
DCOM- 20131219
LR  - 20191027
IS  - 1809-452X (Electronic)
IS  - 1516-4446 (Linking)
VI  - 35
IP  - 1
DP  - 2013 Mar
TI  - Increased BDNF levels in long-term bipolar disorder patients.
PG  - 67-9
LID - S1516-44462013000100012 [pii]
AB  - INTRODUCTION: Bipolar disorder (BD) is a prevalent, chronic and progressive 
      illness. There is a growing body of evidence indicating that brain-derived 
      neurotrophic factor (BDNF) plays an important role in the pathophysiology of BD. 
      OBJECTIVE: The aim of this study was to evaluate BDNF plasma levels in BD 
      patients with long term illness in comparison with controls. METHODS: 87 BD type 
      I patients and 58 controls matched by age, gender and education level were 
      enrolled in this study. All subjects were assessed by the Mini-International 
      Neuropsychiatric Interview and the patients by the Young Mania Rating Scale and 
      the Hamilton Depression Rating Scale. The plasma levels of BDNF were measured by 
      ELISA. RESULTS: On average, patients had suffered from BD for 23.4 years. In 
      comparison with controls, BD patients with mania presented a 1.90-fold increase 
      in BDNF plasma levels (p = .001), while BD patients in remission presented a 
      1.64-fold increase in BDNF plasma levels (p = .03). BDNF plasma levels were not 
      influenced by age, length of illness or current medications. CONCLUSIONS: The 
      present study suggests that long-term BD patients exhibit increased circulating 
      levels of BDNF.
FAU - Barbosa, Izabela Guimaraes
AU  - Barbosa IG
AD  - Graduate Program in Neurosciences, Universidade Federal de Minas Gerais, Brazil.
FAU - Rocha, Natalia Pessoa
AU  - Rocha NP
FAU - Miranda, Aline Silva de
AU  - Miranda AS
FAU - Huguet, Rodrigo Barreto
AU  - Huguet RB
FAU - Bauer, Moises Evandro
AU  - Bauer ME
FAU - Reis, Helton Jose
AU  - Reis HJ
FAU - Teixeira, Antonio Lucio
AU  - Teixeira AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz J Psychiatry
JT  - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
JID - 100895975
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Age Factors
MH  - Biomarkers/blood
MH  - Bipolar Disorder/*blood/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Time Factors
EDAT- 2013/04/10 06:00
MHDA- 2013/12/20 06:00
CRDT- 2013/04/10 06:00
PHST- 2012/03/05 00:00 [received]
PHST- 2012/05/15 00:00 [accepted]
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2013/12/20 06:00 [medline]
AID - S1516-44462013000100012 [pii]
AID - 10.1016/j.rbp.2012.05.011 [doi]
PST - ppublish
SO  - Braz J Psychiatry. 2013 Mar;35(1):67-9. doi: 10.1016/j.rbp.2012.05.011.