PMID- 23567898
OWN - NLM
STAT- MEDLINE
DCOM- 20140109
LR  - 20211021
IS  - 1440-1711 (Electronic)
IS  - 0818-9641 (Print)
IS  - 0818-9641 (Linking)
VI  - 91
IP  - 5
DP  - 2013 May
TI  - Targeted disruption of MCPIP1/Zc3h12a results in fatal inflammatory disease.
PG  - 368-76
LID - 10.1038/icb.2013.11 [doi]
AB  - Previous studies using MCP-induced protein 1 (MCPIP1)/Zc3h12a-deficient mice 
      suggest that MCPIP1 is an important regulator of inflammation and immune 
      homeostasis. However, the characterization of the immunological phenotype of 
      MCPIP1-deficient mice has not been detailed. In this study, we performed 
      evaluation through histological, flow cytometric, enzyme-linked immunosorbent 
      assay and real-time PCR analysis and found that targeted disruption of MCPIP1 
      gene leads to fatal, highly aggressive and widespread immune-related lesions. In 
      addition to previously observed growth retardation, splenomegaly, 
      lymphoadenopathy, severe anemia and premature death, MCPIP1-deficient mice showed 
      disorganization of lymphoid organs, including spleen, lymph nodes and thymus, and 
      massive infiltration of lymphocytes, macrophages and neutrophils into many other 
      non-lymphoid organs, primarily in lungs and liver. Flow cytometric analysis found 
      significant increase in activated and differentiated T cells in peripheral blood 
      and spleen of MCPIP1-deficient mice. Moreover, heightened production of 
      inflammatory cytokines from activated macrophages and T cells were observed in 
      MCPIP1-deficient mice. Interestingly, treatment of MCPIP1-deficient mice with 
      antibiotics resulted in significant improvement of life span and a decrease in 
      inflammatory syndrome. Taken together, these results suggest a prominent role for 
      MCPIP1 in the control of inflammation and immune homeostasis.
FAU - Miao, Ruidong
AU  - Miao R
AD  - Department of Basic Medical Science, School of Medicine, University of 
      Missouri-Kansas City, Kansas City, MO, USA.
FAU - Huang, Shengping
AU  - Huang S
FAU - Zhou, Zhou
AU  - Zhou Z
FAU - Quinn, Tim
AU  - Quinn T
FAU - Van Treeck, Benjamin
AU  - Van Treeck B
FAU - Nayyar, Tehreem
AU  - Nayyar T
FAU - Dim, Daniel
AU  - Dim D
FAU - Jiang, Zhisheng
AU  - Jiang Z
FAU - Papasian, Christopher J
AU  - Papasian CJ
FAU - Eugene Chen, Y
AU  - Eugene Chen Y
FAU - Liu, Gang
AU  - Liu G
FAU - Fu, Mingui
AU  - Fu M
LA  - eng
GR  - HL076206/HL/NHLBI NIH HHS/United States
GR  - R21 HL098794/HL/NHLBI NIH HHS/United States
GR  - R01 HL068878/HL/NHLBI NIH HHS/United States
GR  - HL097218/HL/NHLBI NIH HHS/United States
GR  - HL098794/HL/NHLBI NIH HHS/United States
GR  - R01 HL076206/HL/NHLBI NIH HHS/United States
GR  - R01 HL089544/HL/NHLBI NIH HHS/United States
GR  - HL089544/HL/NHLBI NIH HHS/United States
GR  - HL068878/HL/NHLBI NIH HHS/United States
GR  - R21 HL097218/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130409
PL  - United States
TA  - Immunol Cell Biol
JT  - Immunology and cell biology
JID - 8706300
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (Transcription Factors)
RN  - EC 3.1.- (Ribonucleases)
RN  - EC 3.1.- (ZC3H12A protein, human)
SB  - IM
CIN - Immunol Cell Biol. 2013 May;91(5):331-2. PMID: 23628803
MH  - 3' Untranslated Regions/genetics
MH  - Animals
MH  - Anti-Bacterial Agents/administration & dosage
MH  - Cell Movement/genetics/immunology
MH  - Dysbiosis/drug therapy/genetics/*immunology
MH  - Gene Expression Regulation/genetics/immunology
MH  - Humans
MH  - Immune Tolerance/drug effects/genetics
MH  - Inflammation/*genetics
MH  - Liver/immunology/pathology
MH  - Lung/immunology/pathology
MH  - Mice
MH  - Mice, Knockout
MH  - Microbiota/genetics/immunology
MH  - Mucous Membrane/immunology
MH  - Myeloid Differentiation Factor 88/metabolism
MH  - RNA Stability/immunology
MH  - Ribonucleases
MH  - Transcription Factors/*genetics
PMC - PMC3932977
MID - NIHMS452671
COIS- Conflict of Interest The authors have no financial conflicts of interests.
EDAT- 2013/04/10 06:00
MHDA- 2014/01/10 06:00
PMCR- 2014/02/24
CRDT- 2013/04/10 06:00
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2014/01/10 06:00 [medline]
PHST- 2014/02/24 00:00 [pmc-release]
AID - icb201311 [pii]
AID - 10.1038/icb.2013.11 [doi]
PST - ppublish
SO  - Immunol Cell Biol. 2013 May;91(5):368-76. doi: 10.1038/icb.2013.11. Epub 2013 Apr 
      9.