PMID- 23567920
OWN - NLM
STAT- MEDLINE
DCOM- 20131211
LR  - 20151119
IS  - 1432-069X (Electronic)
IS  - 0340-3696 (Linking)
VI  - 305
IP  - 6
DP  - 2013 Aug
TI  - The relationship between severity of the disease and circulating nucleosomes in 
      psoriasis patients.
PG  - 483-7
LID - 10.1007/s00403-013-1347-4 [doi]
AB  - Psoriasis was initially considered to represent a disease of abnormal epidermal 
      keratinocyte proliferation. Proliferation of keratinocytes is restricted by 
      apoptotic cell death to maintain a constant thickness of epidermis. Nucleosomes 
      are mainly released by apoptotic cells. Tumor necrosis factor-alpha (TNF-alpha) is an 
      important factor affecting the apoptosis. In the present study, the relationship 
      between TNF-alpha, nucleosome and the Psoriasis Area and Severity Index (PASI) score 
      was investigated. The patients were divided according to PASI score into three 
      groups (mild, moderately, severe). Serum TNF-alpha and nucleosome levels were 
      measured using Enzyme-linked immunosorbent assay (ELISA) method. Our findings 
      show a correct relationship between PASI scores and TNF-alpha and an inverse 
      relationship between nucleosome and PASI score. According to the results obtained 
      from the study, we believe that serum nucleosome levels can be used as a new 
      indicator in follow-up of patients with psoriasis and monitoring of the 
      effectiveness of drugs which used in the treatment of psoriasis.
FAU - Dilek, Aziz Ramazan
AU  - Dilek AR
AD  - Microbiology Department of Recep Tayyip Erdogan University, Medical Faculty 
      Hospital, Rize, 53000, Turkey. ar.dilek@hotmail.com
FAU - Dilek, Nursel
AU  - Dilek N
FAU - Saral, Yunus
AU  - Saral Y
FAU - Yuksel, Derya
AU  - Yuksel D
LA  - eng
PT  - Journal Article
DEP - 20130409
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
RN  - 0 (Biomarkers)
RN  - 0 (Nucleosomes)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - *Apoptosis
MH  - Biomarkers/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Keratinocytes/immunology/*pathology
MH  - Male
MH  - Middle Aged
MH  - Nucleosomes/*pathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Psoriasis/blood/diagnosis/immunology/*pathology
MH  - Severity of Illness Index
MH  - Tumor Necrosis Factor-alpha/blood
EDAT- 2013/04/10 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/04/10 06:00
PHST- 2012/12/04 00:00 [received]
PHST- 2013/03/22 00:00 [accepted]
PHST- 2013/03/20 00:00 [revised]
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s00403-013-1347-4 [doi]
PST - ppublish
SO  - Arch Dermatol Res. 2013 Aug;305(6):483-7. doi: 10.1007/s00403-013-1347-4. Epub 
      2013 Apr 9.