PMID- 23568271
OWN - NLM
STAT- MEDLINE
DCOM- 20131223
LR  - 20211021
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 251
IP  - 8
DP  - 2013 Aug
TI  - Vitreal, retinal, and choroidal findings in active and scarred toxoplasmosis 
      lesions: a prospective study by spectral-domain optical coherence tomography.
PG  - 2037-45
LID - 10.1007/s00417-013-2334-3 [doi]
AB  - BACKGROUND: The aim of our study was to investigate vitreal, retinal, and 
      choroidal morphologic changes in active and scarred toxoplasmosis lesions using 
      spectral-domain optical coherence tomography (SD-OCT). METHODS: In this 
      prospective study, 19 eyes of 15 consecutive patients with ocular toxoplasmosis 
      were included. Complete ophthalmologic examination and SD-OCT were done at the 
      initial visit and during follow-up. Retina and choroid SD-OCT protocols directed 
      to macular area and lesions observed on clinical examination were used. RESULTS: 
      Seventeen active lesions and 56 retinochoroidal scars were studied. In the acute 
      phase, disruption, thickening, and hyper-reflectivity of the neurosensory retina 
      with photoreceptor (PR) interruption and retinal pigment epithelial (RPE) 
      elevation were found. The choroid became thickened and hyporeflective. During 
      follow-up, neurosensory retinal layers thinning and disorganization, PR 
      interruption, and RPE elevation and/or atrophy were demonstrated. The choroid 
      returned to normal thickness and became more hyperreflective. Five active lesions 
      presented with hyperreflective oval deposits within the vitreoretinal interface, 
      adjacent to or far away from the lesions. During follow-up, the deposits became 
      smaller, entered into the inner retina layers and faded with time until complete 
      resolution. Multiple hyperreflective dots in the vitreous cavity, compatible with 
      vitritis, and posterior hyaloid thickening were demonstrated in the acute phase, 
      with complete resolution and detachment of the posterior hyaloid during 
      follow-up. Four types of scars were specified according to outer retina-choroid 
      interface changes; atrophic, elevated, deep, and combined (atrophic & elevated). 
      Epiretinal membrane segments were found over active and scarred lesions. 
      CONCLUSIONS: SD-OCT imaging showed toxoplasmic retinochoroidal lesions and scars 
      to be complex and characterized acutely by thickening and disorganization of both 
      the retina and underlying choroid, and following scar formation by varying 
      degrees of thinning, often in conjunction with irregularity of the outer retinal 
      layers.
FAU - Goldenberg, Dafna
AU  - Goldenberg D
AD  - Department of Ophthalmology, Tel Aviv Medical Center, Sackler Faculty of 
      Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel. 
      dafnagoldenberg@gmail.com
FAU - Goldstein, Michaella
AU  - Goldstein M
FAU - Loewenstein, Anat
AU  - Loewenstein A
FAU - Habot-Wilner, Zohar
AU  - Habot-Wilner Z
LA  - eng
PT  - Journal Article
DEP - 20130409
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Glucocorticoids)
RN  - 3U02EL437C (Clindamycin)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Atrophy
MH  - Child
MH  - Choroid Diseases/*diagnosis/drug therapy/parasitology
MH  - Clindamycin/therapeutic use
MH  - Drug Therapy, Combination
MH  - Epiretinal Membrane/diagnosis
MH  - Eye Diseases/*diagnosis/drug therapy/parasitology
MH  - Female
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prednisolone/therapeutic use
MH  - Prospective Studies
MH  - Retinal Diseases/*diagnosis/drug therapy/parasitology
MH  - Retinal Pigment Epithelium/pathology
MH  - *Tomography, Optical Coherence
MH  - Toxoplasmosis, Ocular/*diagnosis/drug therapy/parasitology
MH  - Visual Acuity/physiology
MH  - Vitreous Body/*pathology
MH  - Young Adult
EDAT- 2013/04/10 06:00
MHDA- 2013/12/24 06:00
CRDT- 2013/04/10 06:00
PHST- 2013/01/18 00:00 [received]
PHST- 2013/03/18 00:00 [accepted]
PHST- 2013/03/13 00:00 [revised]
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2013/12/24 06:00 [medline]
AID - 10.1007/s00417-013-2334-3 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2013 Aug;251(8):2037-45. doi: 
      10.1007/s00417-013-2334-3. Epub 2013 Apr 9.