PMID- 23568326
OWN - NLM
STAT- MEDLINE
DCOM- 20140324
LR  - 20211021
IS  - 1740-634X (Electronic)
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 38
IP  - 10
DP  - 2013 Sep
TI  - Social play behavior in adolescent rats is mediated by functional activity in 
      medial prefrontal cortex and striatum.
PG  - 1899-909
LID - 10.1038/npp.2013.83 [doi]
AB  - Social play behavior is a characteristic, vigorous form of social interaction in 
      young mammals. It is highly rewarding and thought to be of major importance for 
      social and cognitive development. The neural substrates of social play are 
      incompletely understood, but there is evidence to support a role for the 
      prefrontal cortex (PFC) and striatum in this behavior. Using pharmacological 
      inactivation methods, ie, infusions of GABA receptor agonists (baclofen and 
      muscimol; B&M) or the AMPA/kainate receptor antagonist 
      6,7-dinitroquinoxaline-2,3(1H,4H)-dione (DNQX), we investigated the involvement 
      of several subregions of the medial PFC and striatum in social play. Inactivation 
      of the prelimbic cortex, infralimbic cortex, and medial/ventral orbitofrontal 
      cortex using B&M markedly reduced frequency and duration of social play behavior. 
      Local administration of DNQX into the dorsomedial striatum increased the 
      frequency and duration of social play, whereas infusion of B&M tended to have the 
      same effect. Inactivation of the nucleus accumbens (NAcc) core using B&M 
      increased duration but not frequency of social play, whereas B&M infusion into 
      the NAcc shell did not influence social play behavior. Thus, functional integrity 
      of the medial PFC is important for the expression of social play behavior. 
      Glutamatergic inputs into the dorsomedial striatum exert an inhibitory influence 
      on social play, and functional activity in the NAcc core acts to limit the length 
      of playful interactions. These results highlight the importance of prefrontal and 
      striatal circuits implicated in cognitive control, decision making, behavioral 
      inhibition, and reward-associated processes in social play behavior.
FAU - van Kerkhof, Linda W M
AU  - van Kerkhof LW
AD  - Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and 
      Pharmacology, University Medical Centre Utrecht, Utrecht, The Netherlands.
FAU - Damsteegt, Ruth
AU  - Damsteegt R
FAU - Trezza, Viviana
AU  - Trezza V
FAU - Voorn, Pieter
AU  - Voorn P
FAU - Vanderschuren, Louk J M J
AU  - Vanderschuren LJ
LA  - eng
GR  - R01 DA022628/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130408
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (GABA-B Receptor Agonists)
RN  - 0 (Quinoxalines)
RN  - 2763-96-4 (Muscimol)
RN  - 62T278S1MX (FG 9041)
RN  - H789N3FKE8 (Baclofen)
SB  - IM
MH  - Animals
MH  - Baclofen/administration & dosage/pharmacology
MH  - Corpus Striatum/drug effects/*physiology
MH  - Excitatory Amino Acid Antagonists/administration & dosage/pharmacology
MH  - GABA-B Receptor Agonists/administration & dosage/pharmacology
MH  - Male
MH  - Microinjections
MH  - Muscimol/administration & dosage/pharmacology
MH  - Nucleus Accumbens/drug effects/physiology
MH  - Prefrontal Cortex/drug effects/*physiology
MH  - Quinoxalines/administration & dosage/pharmacology
MH  - Rats
MH  - *Social Behavior
PMC - PMC3746695
EDAT- 2013/04/10 06:00
MHDA- 2014/03/25 06:00
PMCR- 2014/09/01
CRDT- 2013/04/10 06:00
PHST- 2012/12/07 00:00 [received]
PHST- 2013/03/29 00:00 [revised]
PHST- 2013/04/03 00:00 [accepted]
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2014/03/25 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - npp201383 [pii]
AID - 10.1038/npp.2013.83 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2013 Sep;38(10):1899-909. doi: 10.1038/npp.2013.83. Epub 
      2013 Apr 8.