PMID- 23568719
OWN - NLM
STAT- MEDLINE
DCOM- 20130723
LR  - 20130409
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 30
IP  - 2
DP  - 2013 Apr
TI  - [Genetic characteristics and its prognostic significance for 217 adult patients 
      with acute lymphoblastic leukemia].
PG  - 129-33
LID - 10.3760/cma.j.issn.1003-9406.2013.04.001 [doi]
AB  - OBJECTIVE: To evaluate cyto- and molecular genetic characteristics of adult 
      patients with acute lymphoblastic leukemia (ALL) and its prognostic significance. 
      METHODS: Two hundred and seventeen adult patients with ALL were analyzed for 
      cyto- and molecular genetic characteristics with combined conventional 
      cytogenetics, fluorescence in situ hybridization (FISH), real-time quantitative 
      PCR (qPCR) and nested PCR. Significance of genetic findings for prognosis was 
      evaluated. RESULTS: t(9;22)(q34;q11)/BCR-ABL has been the most frequent 
      abnormality found in the cohort (56.3%). And 22.4% of cases with BCR-ABL detected 
      by FISH was negative by cytogenetic analysis. Ratio of patients in high-risk 
      group increased with age; Patients with B-ALL had a higher risk group than the 
      average-risk group (98.40% vs. 65.70%, P=0.000). The overall survival (OS) rates 
      at 3-month (67.30% vs. 85.10%, P=0.042), 6-month (55.1% vs. 80.4%, P=0.008), 
      12-month (34.0% vs. 59.1%, P=0.017) and 24-month (13.0% vs. 36.6%, P=0.010) were 
      lower in high-risk group than in average-risk group, with medium OS time (11 
      months, 95% CI 8.0-13.9) being significantly shorter compared with the 
      average-risk group (19 months, 95%CI 10.8-27.1). CONCLUSION: Adult patients with 
      ALL have unique cyto- and molecular genetic characteristics, which has important 
      value for prognosis and guiding treatment. Moreover, combined cytogenetic and 
      molecular genetic techniques can precisely define sub-groups of ALL patients.
FAU - Liu, Juan
AU  - Liu J
AD  - Department of Hematology, The First Affiliated Hospital, Nanjing Medical 
      University, Jiangsu Province Hospital, P.R. China.
FAU - Zhang, Run
AU  - Zhang R
FAU - Ge, Zheng
AU  - Ge Z
FAU - Lin, Zhong-kun
AU  - Lin ZK
FAU - Liu, Ping
AU  - Liu P
FAU - Qiu, Hai-rong
AU  - Qiu HR
FAU - Zhu, Guang-rong
AU  - Zhu GR
FAU - Yang, Hui
AU  - Yang H
FAU - Wu, Yujie
AU  - Wu Y
FAU - Qiao, Chun
AU  - Qiao C
FAU - Zhang, Jian-fu
AU  - Zhang JF
FAU - Li, Jian-yong
AU  - Li JY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics/mortality
MH  - Prognosis
EDAT- 2013/04/10 06:00
MHDA- 2013/07/24 06:00
CRDT- 2013/04/10 06:00
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2013/07/24 06:00 [medline]
AID - 940630031 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2013.04.001 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013 Apr;30(2):129-33. doi: 
      10.3760/cma.j.issn.1003-9406.2013.04.001.