PMID- 23568721
OWN - NLM
STAT- MEDLINE
DCOM- 20130723
LR  - 20130409
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 30
IP  - 2
DP  - 2013 Apr
TI  - [Clinical and cytogenetic study of 6 cases of hematological disorders associated 
      with 20q- and t (20;21) (q11;q11) abnormalities].
PG  - 138-42
LID - 10.3760/cma.j.issn.1003-9406.2013.04.003 [doi]
AB  - OBJECTIVE: To analyze clinical and cytogenetic features of hematological 
      disorders associated with 20q- and t (20;21) (q11;q11) abnormalities. METHODS: 
      Following short-term culture of bone marrow cells, karyotypic analysis was 
      carried out with R-banding. 20q- and t(20;21) (q11;q11) was detected by 
      fluorescence in situ hybridization (FISH) using dual-color 20q11/12 probe, ST 
      20qter /ST 21qter probes, SE20(D20Z1)/SE 13/21 probes, and WC20/WC21 probes. 
      RESULTS: Six (2.3%) of the 257 patients with 20q- detected by conventional 
      karyotypic analysis were found to have t(20;21) (q11;q11) abnormality. Five cases 
      had myelodysplastic syndrome, 1 had acute lymphoblastic leukemia. Above results 
      were all confirmed by FISH. CONCLUSION: i (20q-), t(20;21) (q11;q11) seems to be 
      a rare but recurrent chromosomal abnormality which is specifically associated 
      with myeloid disease, late occurrence and poor prognosis. The translocation 
      between chromosome 20q11 and 21q11 may form a novel fusion gene which has an 
      important role in the pathogenesis of the disease.
FAU - Wu, Chun-xiao
AU  - Wu CX
AD  - Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis, The 
      First Affiliated Hospital of Soochow University, Suzhou, P.R. China.
FAU - Pan, Jin-lan
AU  - Pan JL
FAU - Qiu, Hui-ying
AU  - Qiu HY
FAU - Xue, Yong-quan
AU  - Xue YQ
FAU - Chen, Su-ning
AU  - Chen SN
FAU - Zhang, Jun
AU  - Zhang J
FAU - Wu, Ya-fang
AU  - Wu YF
FAU - Shen, Juan
AU  - Shen J
FAU - Bai, Shu-xiao
AU  - Bai SX
FAU - Wang, Yong
AU  - Wang Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Aged
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 20
MH  - *Chromosomes, Human, Pair 21
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - *Translocation, Genetic
EDAT- 2013/04/10 06:00
MHDA- 2013/07/24 06:00
CRDT- 2013/04/10 06:00
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2013/07/24 06:00 [medline]
AID - 940630033 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2013.04.003 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013 Apr;30(2):138-42. doi: 
      10.3760/cma.j.issn.1003-9406.2013.04.003.