PMID- 23568725
OWN - NLM
STAT- MEDLINE
DCOM- 20130723
LR  - 20130409
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 30
IP  - 2
DP  - 2013 Apr
TI  - [Clinical and laboratory investigation of pericentric inv(9)(p22q34) with the 
      der(9)t(9;22)(q34;q11) in Ph-positive leukemia].
PG  - 157-60
LID - 10.3760/cma.j.issn.1003-9406.2013.04.007 [doi]
AB  - OBJECTIVE: To investigate clinical and molecule genetics features of four 
      Ph-positive leukemia patients characterized by pericentric inv(9)(p22q34) with 
      the der(9)t(9;22)(q34;q11). METHODS: Cytogenetic analysis was carried out on bone 
      marrow directly or after short-period culture. R banding was used for karyotype 
      analysis. BCR/ABL fusion gene was detected with interphase fluorescence in situ 
      hybridization (FISH), and chromosome painting was carried out using specific 
      probes. RT-PCR was used to detect BCR/ABL chimeric transcripts. RESULTS: One 
      patient with acute myeloid leukemia (AML) presented three clones, which included 
      one with a normal karyotype, one with t(9;22)(q34;q11), and one with 
      inv(9)(p22q34) involving the der(9)t(9;22) and additional t(8;12)(q12;p11). The 
      inv(9)(p22q34) has always co-occurred with der(9)t(9;22)(q34;q11) accompanied by 
      der(22)t(9;22)(q34;q11) in all metaphases from the three patients with chronic 
      myeloid leukemia (CML). B3a2 transcript was detected in all patients by RT-PCR. 
      Inv(9)(p22q34) was found in both CML and AML, and was associated with poor 
      prognosis. CONCLUSION: Inv(9)(p22q34) is a novel, rare, but recurrent secondary 
      chromosomal abnormality for Ph-positive leukemia. Leukemia with der(9)t(9;22) and 
      inv(9)(p22q34) has unique clinical and laboratory characteristics.
FAU - Fan, Yisun
AU  - Fan Y
AD  - Department of Clinical Laboratory, Suzhou Kowloon Hospital, Shanghai Jiao Tong 
      University Medical School, P.R. China.
FAU - Ding, Shuang-shuang
AU  - Ding SS
FAU - Pan, Jin-lan
AU  - Pan JL
FAU - Xue, Yong-quan
AU  - Xue YQ
FAU - Hu, Zhen-hua
AU  - Hu ZH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Adult
MH  - *Chromosome Inversion
MH  - *Chromosomes, Human, Pair 22
MH  - *Chromosomes, Human, Pair 9
MH  - Female
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Translocation, Genetic
EDAT- 2013/04/10 06:00
MHDA- 2013/07/24 06:00
CRDT- 2013/04/10 06:00
PHST- 2013/04/10 06:00 [entrez]
PHST- 2013/04/10 06:00 [pubmed]
PHST- 2013/07/24 06:00 [medline]
AID - 940630037 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2013.04.007 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013 Apr;30(2):157-60. doi: 
      10.3760/cma.j.issn.1003-9406.2013.04.007.