PMID- 23569534
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130410
LR  - 20211021
IS  - 1941-5923 (Electronic)
IS  - 1941-5923 (Linking)
VI  - 13
DP  - 2012
TI  - Multiple endocrine neoplasia type 1- presenting multiple lipomas and hypoglycemia 
      onset.
PG  - 224-9
LID - 10.12659/AJCR.883383 [doi]
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1), also called Wermer 
      syndrome, is an autosomal dominant disorder characterized by tumors of the 
      parathyroid glands, the anterior pituitary, and the endocrine pancreas. CASE 
      REPORT: Here, we report a case of MEN1. Our patient was a 44-year-old woman who 
      manifested typical features of MEN1, including insulinoma, pituitary tumors, and 
      parathyroidoma, and exhibited multiple lipomas and a gastrinoma with duodenal 
      ulcers. She was admitted to our hospital because of recurrent massive bleeding of 
      the upper gastrointestinal tract and hypoglycemia. The first operation for 
      pituitary tumors was performed when she was 40 years old. According to these 
      examinations and her clinical course, the patient was diagnosed with insulinoma 
      and gastrinoma. She subsequently underwent surgery for the pancreatic tumors. The 
      majority of these tumor cells were immunohistochemically positive for insulin and 
      negative for glucagon. CONCLUSIONS: This case suggests that multiple lipomas, 
      insulinoma and gastrinoma may provide clues for a diagnosis of MEN1.
FAU - Li, Jianzhong
AU  - Li J
AD  - Department of Gastroenterology, Third Affiliated Hospital of Sun Yat-Sen 
      University, Guangzhou, China.
FAU - Zeng, Lixian
AU  - Zeng L
FAU - Yang, Yidong
AU  - Yang Y
FAU - Zhan, Yashi
AU  - Zhan Y
FAU - Tao, Jin
AU  - Tao J
FAU - Wu, Bin
AU  - Wu B
LA  - eng
PT  - Journal Article
DEP - 20120910
PL  - United States
TA  - Am J Case Rep
JT  - The American journal of case reports
JID - 101489566
PMC - PMC3616096
OTO - NOTNLM
OT  - gastrinoma
OT  - insulinoma
OT  - multiple endocrine neoplasia type 1
OT  - multiple lipomas
OT  - upper gastrointestinal bleeding
EDAT- 2012/01/01 00:00
MHDA- 2012/01/01 00:01
PMCR- 2012/09/10
CRDT- 2013/04/10 06:00
PHST- 2011/10/26 00:00 [received]
PHST- 2011/12/20 00:00 [accepted]
PHST- 2013/04/10 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2012/01/01 00:01 [medline]
PHST- 2012/09/10 00:00 [pmc-release]
AID - 883383 [pii]
AID - 10.12659/AJCR.883383 [doi]
PST - ppublish
SO  - Am J Case Rep. 2012;13:224-9. doi: 10.12659/AJCR.883383. Epub 2012 Sep 10.