PMID- 23570576
OWN - NLM
STAT- MEDLINE
DCOM- 20130528
LR  - 20211021
IS  - 1557-7430 (Electronic)
IS  - 1044-5498 (Print)
IS  - 1044-5498 (Linking)
VI  - 32
IP  - 4
DP  - 2013 Apr
TI  - Mast cells: a pivotal role in pulmonary fibrosis.
PG  - 206-18
LID - 10.1089/dna.2013.2005 [doi]
AB  - Pulmonary fibrosis is characterized by an inflammatory response that includes 
      macrophages, neutrophils, lymphocytes, and mast cells. The purpose of this study 
      was to evaluate whether mast cells play a role in initiating pulmonary fibrosis. 
      Pulmonary fibrosis was induced with bleomycin in mast-cell-deficient 
      WBB6F1-W/W(v) (MCD) mice and their congenic controls (WBB6F1-(+)/(+)). Mast cell 
      deficiency protected against bleomycin-induced pulmonary fibrosis, but protection 
      was reversed with the re-introduction of mast cells to the lungs of MCD mice. Two 
      mast cell mediators were identified as fibrogenic: histamine and renin, via 
      angiotensin (ANG II). Both human and rat lung fibroblasts express the histamine 
      H1 and ANG II AT1 receptor subtypes and when activated, they promote 
      proliferation, transforming growth factor beta1 secretion, and collagen synthesis. 
      Mast cells appear to be critical to pulmonary fibrosis. Therapeutic blockade of 
      mast cell degranulation and/or histamine and ANG II receptors should attenuate 
      pulmonary fibrosis.
FAU - Veerappan, Arul
AU  - Veerappan A
AD  - Department of Physiology and Biophysics, Weill Cornell Medical College, New York, 
      NY 10065, USA.
FAU - O'Connor, Nathan J
AU  - O'Connor NJ
FAU - Brazin, Jacqueline
AU  - Brazin J
FAU - Reid, Alicia C
AU  - Reid AC
FAU - Jung, Albert
AU  - Jung A
FAU - McGee, David
AU  - McGee D
FAU - Summers, Barbara
AU  - Summers B
FAU - Branch-Elliman, Dascher
AU  - Branch-Elliman D
FAU - Stiles, Brendon
AU  - Stiles B
FAU - Worgall, Stefan
AU  - Worgall S
FAU - Kaner, Robert J
AU  - Kaner RJ
FAU - Silver, Randi B
AU  - Silver RB
LA  - eng
GR  - R01 HL 073400/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - DNA Cell Biol
JT  - DNA and cell biology
JID - 9004522
RN  - 0 (Antibiotics, Antineoplastic)
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 11056-06-7 (Bleomycin)
RN  - 11128-99-7 (Angiotensin II)
RN  - 820484N8I3 (Histamine)
RN  - 9007-34-5 (Collagen)
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Angiotensin II/metabolism
MH  - Animals
MH  - Antibiotics, Antineoplastic/*toxicity
MH  - Bleomycin/*toxicity
MH  - Blotting, Western
MH  - Cell Proliferation/*drug effects
MH  - Collagen/metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Fibroblasts/drug effects/metabolism/*pathology
MH  - Histamine/metabolism
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Lung/drug effects/metabolism/*pathology
MH  - Male
MH  - Mast Cells/cytology/drug effects/*physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Pulmonary Fibrosis/chemically induced/drug therapy/*pathology
MH  - Radioimmunoassay
MH  - Rats
MH  - Receptor, Angiotensin, Type 1/metabolism
MH  - Renin/metabolism
MH  - Transforming Growth Factor beta1/metabolism
PMC - PMC3624698
EDAT- 2013/04/11 06:00
MHDA- 2013/05/29 06:00
PMCR- 2014/04/01
CRDT- 2013/04/11 06:00
PHST- 2013/04/11 06:00 [entrez]
PHST- 2013/04/11 06:00 [pubmed]
PHST- 2013/05/29 06:00 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - 10.1089/dna.2013.2005 [pii]
AID - 10.1089/dna.2013.2005 [doi]
PST - ppublish
SO  - DNA Cell Biol. 2013 Apr;32(4):206-18. doi: 10.1089/dna.2013.2005.