PMID- 23570723
OWN - NLM
STAT- MEDLINE
DCOM- 20140106
LR  - 20151119
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 544
DP  - 2013 Jun 7
TI  - Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with 
      narcolepsy.
PG  - 31-5
LID - S0304-3940(13)00272-3 [pii]
LID - 10.1016/j.neulet.2013.03.031 [doi]
AB  - Narcolepsy is a lifelong sleep disorder characterized by excessive daytime 
      sleepiness, sudden loss of muscle tone (cataplexy), fragmentation of nocturnal 
      sleep and sleep paralysis. The symptoms of the disease strongly correlate with a 
      reduction in hypocretin levels in CSF and a reduction in hypocretin neurons in 
      hypothalamus in post-mortem tissue. Brain-derived neurotrophic factor (BDNF) and 
      nerve growth factor (NGF) are important for activity-dependent neuronal function 
      and synaptic modulation and it is considered that these mechanisms are important 
      in sleep regulation. We hypothesized that serum levels of these factors are 
      altered in patients with narcolepsy compared to healthy controls without sleep 
      disturbances. Polysomnography data was obtained and serum BDNF and NGF levels 
      measured using ELISA, while hypocretin was measured using RIA. Serum BDNF levels 
      were significantly higher in narcolepsy patients than in healthy controls 
      (64.2+/-3.9 ng/ml vs. 47.3+/-2.6 ng/ml, P<0.01), while there were no significant 
      differences in NGF levels. As expected, narcolepsy patients had higher BMI 
      compared to controls, but BMI did not correlate with the serum BDNF levels. The 
      change in BDNF levels was not related to disease duration and sleep parameters 
      did not correlate with BDNF in narcolepsy patients. The mechanisms behind the 
      marked increase in BDNF levels in narcolepsy patients remain unknown.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Klein, Anders B
AU  - Klein AB
AD  - Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, 
      Denmark.
FAU - Jennum, Poul
AU  - Jennum P
FAU - Knudsen, Stine
AU  - Knudsen S
FAU - Gammeltoft, Steen
AU  - Gammeltoft S
FAU - Mikkelsen, Jens D
AU  - Mikkelsen JD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130406
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neuropeptides)
RN  - 0 (Orexins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Body Mass Index
MH  - Female
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*cerebrospinal fluid
MH  - Male
MH  - Middle Aged
MH  - Narcolepsy/*blood/*cerebrospinal fluid/physiopathology
MH  - Nerve Growth Factors/*blood
MH  - Neuropeptides/*cerebrospinal fluid
MH  - Orexins
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2013/04/11 06:00
MHDA- 2014/01/07 06:00
CRDT- 2013/04/11 06:00
PHST- 2012/11/27 00:00 [received]
PHST- 2013/02/21 00:00 [revised]
PHST- 2013/03/11 00:00 [accepted]
PHST- 2013/04/11 06:00 [entrez]
PHST- 2013/04/11 06:00 [pubmed]
PHST- 2014/01/07 06:00 [medline]
AID - S0304-3940(13)00272-3 [pii]
AID - 10.1016/j.neulet.2013.03.031 [doi]
PST - ppublish
SO  - Neurosci Lett. 2013 Jun 7;544:31-5. doi: 10.1016/j.neulet.2013.03.031. Epub 2013 
      Apr 6.