PMID- 23570887
OWN - NLM
STAT- MEDLINE
DCOM- 20141009
LR  - 20240420
IS  - 1545-7214 (Electronic)
IS  - 1064-7481 (Print)
IS  - 1064-7481 (Linking)
VI  - 21
IP  - 5
DP  - 2013 May
TI  - Involvement of brain-derived neurotrophic factor in late-life depression.
PG  - 433-49
LID - S1064-7481(12)00062-0 [pii]
LID - 10.1016/j.jagp.2012.10.026 [doi]
AB  - Brain-derived neurotrophic factor (BDNF), one of the major neurotrophic factors, 
      plays an important role in the maintenance and survival of neurons, synaptic 
      integrity, and synaptic plasticity. Evidence suggests that BDNF is involved in 
      major depression, such that the level of BDNF is decreased in depressed patients 
      and that antidepressants reverse this decrease. Stress, a major factor in 
      depression, also modulates BDNF expression. These studies have led to the 
      proposal of the neurotrophin hypothesis of depression. Late-life depression is 
      associated with disturbances in structural and neural plasticity as well as 
      impairments in cognitive behavior. Stress and aging also play a crucial role in 
      late-life depression. Many recent studies have suggested that not only expression 
      of BDNF is decreased in the serum/plasma of patients with late-life depression, 
      but structural abnormalities in the brain of these patients may be associated 
      with a polymorphism in the BDNF gene, and that there is a relationship between a 
      BDNF polymorphism and antidepressant remission rates. This review provides a 
      critical review of the involvement of BDNF in major depression, in general, and 
      in late-life depression, in particular.
CI  - Copyright (c) 2013 American Association for Geriatric Psychiatry. Published by 
      Elsevier Inc. All rights reserved.
FAU - Dwivedi, Yogesh
AU  - Dwivedi Y
AD  - Psychiatric Institute, Department of Psychiatry, College of Medicine, University 
      of Illinois at Chicago, Chicago, IL 60612, USA. ydwivedi@psych.uic.edu
LA  - eng
GR  - R21 MH081099/MH/NIMH NIH HHS/United States
GR  - MH081099/MH/NIMH NIH HHS/United States
GR  - MH082802/MH/NIMH NIH HHS/United States
GR  - R01 MH082802/MH/NIMH NIH HHS/United States
GR  - R21 MH091509/MH/NIMH NIH HHS/United States
GR  - MH091509/MH/NIMH NIH HHS/United States
GR  - F31 NR015725/NR/NINR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130319
PL  - England
TA  - Am J Geriatr Psychiatry
JT  - The American journal of geriatric psychiatry : official journal of the American 
      Association for Geriatric Psychiatry
JID - 9309609
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aging/genetics/metabolism/*psychology
MH  - Animals
MH  - Antidepressive Agents/pharmacology/therapeutic use
MH  - Brain/drug effects/*metabolism/pathology
MH  - Brain-Derived Neurotrophic Factor/drug effects/genetics/*metabolism
MH  - Depression/drug therapy/genetics/*metabolism/pathology
MH  - Gene Expression Regulation/drug effects/genetics/physiology
MH  - Humans
MH  - Neuronal Plasticity/physiology
MH  - Stress, Psychological/metabolism
PMC - PMC3767381
MID - NIHMS458904
EDAT- 2013/04/11 06:00
MHDA- 2014/10/10 06:00
PMCR- 2014/05/01
CRDT- 2013/04/11 06:00
PHST- 2012/01/23 00:00 [received]
PHST- 2012/10/16 00:00 [revised]
PHST- 2012/10/26 00:00 [accepted]
PHST- 2013/04/11 06:00 [entrez]
PHST- 2013/04/11 06:00 [pubmed]
PHST- 2014/10/10 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - S1064-7481(12)00062-0 [pii]
AID - 10.1016/j.jagp.2012.10.026 [doi]
PST - ppublish
SO  - Am J Geriatr Psychiatry. 2013 May;21(5):433-49. doi: 10.1016/j.jagp.2012.10.026. 
      Epub 2013 Mar 19.