PMID- 23571126
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20220409
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 80
DP  - 2013 Jun
TI  - Preparation and optimization of chitosan nanoparticles and magnetic chitosan 
      nanoparticles as delivery systems using Box-Behnken statistical design.
PG  - 141-6
LID - S0731-7085(13)00106-4 [pii]
LID - 10.1016/j.jpba.2013.02.038 [doi]
AB  - Chitosan nanoparticles and magnetic chitosan nanoparticles can be applied as 
      delivery systems for the anti-Alzheimer drug tacrine. Investigation was carried 
      out to elucidate the influence of process parameters on the mean particle size of 
      chitosan nanoparticles produced by spontaneous emulsification. The method was 
      optimized using design of experiments (DOE) by employing a 3-factor, 3-level 
      Box-Behnken statistical design. This statistical design is used in order to 
      achieve the minimum size and suitable morphology of nanoparticles. Also, magnetic 
      chitosan nanoparticles were synthesized according to optimal method. The designed 
      nanoparticles have average particle size from 33.64 to 74.87nm, which were 
      determined by field emission scanning electron microscopy (FE-SEM). Drug loading 
      in the nanoparticles as drug delivery systems has been done according to the 
      presented optimal method and appropriate capacity of drug loading was shown by 
      ultraviolet spectrophotometry. Chitosan and magnetic chitosan nanoparticles as 
      drug delivery systems were characterized by Diffuse Reflectance Fourier Transform 
      Mid Infrared spectroscopy (DR-FTMIR).
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Elmizadeh, Hamideh
AU  - Elmizadeh H
AD  - Department of Chemistry, Faculty of Science, IKIU, Qazvin, Iran. 
      k.elmizadeh@yahoo.com
FAU - Khanmohammadi, Mohammadreza
AU  - Khanmohammadi M
FAU - Ghasemi, Keyvan
AU  - Ghasemi K
FAU - Hassanzadeh, Gholamreza
AU  - Hassanzadeh G
FAU - Nassiri-Asl, Marjan
AU  - Nassiri-Asl M
FAU - Garmarudi, Amir Bagheri
AU  - Garmarudi AB
LA  - eng
PT  - Journal Article
DEP - 20130318
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Emulsions)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Nootropic Agents)
RN  - 4VX7YNB537 (Tacrine)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Chitosan/*chemistry
MH  - Drug Compounding
MH  - Drug Delivery Systems
MH  - Emulsions
MH  - *Magnetite Nanoparticles
MH  - Microscopy, Electron, Scanning
MH  - *Nanoparticles
MH  - Nootropic Agents/administration & dosage
MH  - Particle Size
MH  - Spectroscopy, Fourier Transform Infrared/methods
MH  - Tacrine/*administration & dosage
EDAT- 2013/04/11 06:00
MHDA- 2013/11/13 06:00
CRDT- 2013/04/11 06:00
PHST- 2012/10/04 00:00 [received]
PHST- 2013/02/21 00:00 [revised]
PHST- 2013/02/26 00:00 [accepted]
PHST- 2013/04/11 06:00 [entrez]
PHST- 2013/04/11 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - S0731-7085(13)00106-4 [pii]
AID - 10.1016/j.jpba.2013.02.038 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2013 Jun;80:141-6. doi: 10.1016/j.jpba.2013.02.038. Epub 
      2013 Mar 18.