PMID- 23573124
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20220309
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2013
DP  - 2013
TI  - Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I 
      Induced by Chronic Unpredictable Mild Stress.
PG  - 359682
LID - 10.1155/2013/359682 [doi]
LID - 359682
AB  - Background. Our previous study has demonstrated that nobiletin could reverse the 
      behavioral alterations in stressed mice. However, the relation of its 
      antidepressant-like action with neurotrophic molecular expression remains 
      unknown. This study aimed to explore the antidepressant-like mechanism of 
      nobiletin related to the neurotrophic system in rats exposed to chronic 
      unpredictable mild stress (CUMS). Methods. Depressive-like anhedonia (assessed by 
      sucrose preference) and serum corticosterone secretion were evaluated in the 
      CUMS, followed by brain-derived neurotrophic factor (BDNF), its 
      tropomyosin-related kinase receptor B (TrkB), and the downstream target synapsin 
      I expressions in the hippocampus. Results. Anhedonia, which occurred within week 
      2, was rapidly ameliorated by nobiletin. While fluoxetine needed additional 2 
      weeks to improve the anhedonia. In addition, nobiletin administration for 5 weeks 
      significantly ameliorated CUMS-induced increase in serum corticosterone levels. 
      Furthermore, we also found that CUMS-induced deficits of hippocampal BDNF, TrkB, 
      and synapsin I were ameliorated by nobiletin. Conclusions. Taken together, these 
      findings suggest that nobiletin produces rapidly acting antidepressant-like 
      responses in the CUMS and imply that BDNF-TrkB pathway may play an important role 
      in the antidepressant-like effect of nobiletin.
FAU - Li, Jing
AU  - Li J
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen, Fujian 361021, China.
FAU - Zhou, Ying
AU  - Zhou Y
FAU - Liu, Bin-Bin
AU  - Liu BB
FAU - Liu, Qing
AU  - Liu Q
FAU - Geng, Di
AU  - Geng D
FAU - Weng, Lian-Jin
AU  - Weng LJ
FAU - Yi, Li-Tao
AU  - Yi LT
LA  - eng
PT  - Journal Article
DEP - 20130317
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3613093
EDAT- 2013/04/11 06:00
MHDA- 2013/04/11 06:01
PMCR- 2013/03/17
CRDT- 2013/04/11 06:00
PHST- 2012/11/03 00:00 [received]
PHST- 2013/02/14 00:00 [revised]
PHST- 2013/02/14 00:00 [accepted]
PHST- 2013/04/11 06:00 [entrez]
PHST- 2013/04/11 06:00 [pubmed]
PHST- 2013/04/11 06:01 [medline]
PHST- 2013/03/17 00:00 [pmc-release]
AID - 10.1155/2013/359682 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2013;2013:359682. doi: 10.1155/2013/359682. 
      Epub 2013 Mar 17.