PMID- 23573311
OWN - NLM
STAT- MEDLINE
DCOM- 20131031
LR  - 20211021
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 6
IP  - 4
DP  - 2013
TI  - Gestational diabetes induces chronic hypoxia stress and excessive inflammatory 
      response in murine placenta.
PG  - 650-9
AB  - Metabolic impairments in maternal obesity and gestational diabetes mellitus (GDM) 
      induce an abnormal environment in peripheral blood and cause vascular structure 
      alterations which affect the placental development and function. A GDM model was 
      developed using C57BL/6J female mice fed with high fat food (HF) (40% energy from 
      fat) and a control group with control food (CF) (14% energy from fat) for 14 
      weeks before mating and throughout the gestation period. A subset of dams was 
      sacrificed at gestational day (GD) 18.5 to evaluate the fetal and placental 
      development. HF-fed dams exhibited significant increase in the maternal weight 
      gain and homeostasis model assessment for insulin resistance index (HOMA-IR), 
      impaired insulin secretion of glucose stimulus and glucose clearance of insulin 
      stimulus before pregnancy; in addition, they also had the increase in the fetal 
      and placental weight. HF-fed dams at GD 18.5 showed the high level of circulating 
      maternal inflammation factors and were associated with increased oxidative stress 
      and hypoxia in the labyrinth, abnormal vascular development with a high level of 
      hypoxia inducible factor-1alpha (HIF-1alpha) and VEGF-A expression, but without a 
      parallel increase in CD31 level; were induced an exaggerated inflammatory 
      response in placental vascular endothelial cell. Our findings show that GDM 
      induces more maternal weight gain and fetus weight, with abnormal maternal 
      circulating metabolic and inflammation factors, and forms a placental hypoxia 
      environment and impacts the placental vascular development. Our findings indicate 
      that gestational diabetes induce excessive chronic hypoxia stress and 
      inflammatory response in placentas which may contribute mechanisms to the high 
      risks of perinatal complications of obesity and GDM mothers.
FAU - Li, Hua-Ping
AU  - Li HP
AD  - Department of Gynecology & Obstetrics, 6th People's Hospital affiliated to 
      Shanghai Jiaotong University, Shanghai 6th People's Hospital, Shanghai 200233, 
      China. hpli819@sohu.com
FAU - Chen, Xuan
AU  - Chen X
FAU - Li, Ming-Qing
AU  - Li MQ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130315
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Hif1a protein, mouse)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Insulin)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Comorbidity
MH  - Diabetes, Gestational/epidemiology/metabolism/*physiopathology
MH  - Diet, High-Fat/adverse effects
MH  - Disease Models, Animal
MH  - Female
MH  - Fetal Development
MH  - Glucose/metabolism
MH  - Hypoxia/etiology/metabolism/*physiopathology
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Inflammation/etiology/metabolism/*physiopathology
MH  - Insulin/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/epidemiology/metabolism/physiopathology
MH  - Placenta/metabolism/pathology/*physiopathology
MH  - Pregnancy
MH  - Pregnancy Complications/epidemiology/metabolism/*physiopathology
MH  - Pregnancy, Animal/metabolism/*physiology
MH  - Stress, Physiological/*physiology
MH  - Vascular Endothelial Growth Factor A/metabolism
PMC - PMC3606854
OTO - NOTNLM
OT  - GDM
OT  - High fat diet
OT  - hypoxia
OT  - inflammation factor
OT  - obesity
OT  - oxidative stress
OT  - placenta
EDAT- 2013/04/11 06:00
MHDA- 2013/11/01 06:00
PMCR- 2013/03/15
CRDT- 2013/04/11 06:00
PHST- 2013/01/13 00:00 [received]
PHST- 2013/02/22 00:00 [accepted]
PHST- 2013/04/11 06:00 [entrez]
PHST- 2013/04/11 06:00 [pubmed]
PHST- 2013/11/01 06:00 [medline]
PHST- 2013/03/15 00:00 [pmc-release]
PST - ppublish
SO  - Int J Clin Exp Pathol. 2013;6(4):650-9. Epub 2013 Mar 15.