PMID- 23573829
OWN - NLM
STAT- MEDLINE
DCOM- 20140813
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 55
IP  - 1
DP  - 2014 Jan
TI  - IRF8 is associated with germinal center B-cell-like type of diffuse large B-cell 
      lymphoma and exceptionally involved in translocation t(14;16)(q32.33;q24.1).
PG  - 136-42
LID - 10.3109/10428194.2013.793324 [doi]
AB  - Chromosomal translocations involving the immunoglobulin loci represent frequent 
      oncogenic events in B-cell lymphoma development. Although IRF8 (ICSBP-1) protein 
      expression has been demonstrated in germinal center B-cells and related lymphomas 
      in a single report, the IRF8 gene was not described as an immunoglobulin heavy 
      chain (IGH) translocation partner. In a discovery-driven approach we searched for 
      new translocation partners of IGH in diffuse large B-cell lymphoma (DLBCL) by 
      long distance inverse polymerase chain reaction (LDI-PCR) and Sanger sequencing. 
      A t(14;16)(q32.33;q24.1) IGH/IRF8 was detected in a CD5+de novo DLBCL, confirmed 
      by translocation specific PCR and fluorescence in situ hybridization (FISH) 
      analysis. No further IRF8 aberration could be identified either by LDI-PCR in an 
      additional five CD5+DLBCLs or by FISH on 78 formalin-fixed paraffin-embedded 
      biopsies. Subsequent screening for IRF8 by immunohistochemistry revealed IRF8 
      expression in 18/78 (23%), correlating with a germinal center B-cell-like (GCB) 
      type of DLBCL. This hitherto unknown translocation t(14;16)(q32.33;q24.1) is 
      likely to represent the initiator of a multistep lymphomagenesis in a CD5+de novo 
      DLBCL.
FAU - Tinguely, Marianne
AU  - Tinguely M
AD  - Institute of Surgical Pathology, University Hospital Zurich , Zurich , 
      Switzerland.
FAU - Thies, Svenja
AU  - Thies S
FAU - Frigerio, Simona
AU  - Frigerio S
FAU - Reineke, Tanja
AU  - Reineke T
FAU - Korol, Dimitri
AU  - Korol D
FAU - Zimmermann, Dieter R
AU  - Zimmermann DR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130612
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Antigens, CD20)
RN  - 0 (CD5 Antigens)
RN  - 0 (Interferon Regulatory Factors)
RN  - 0 (interferon regulatory factor-8)
SB  - IM
MH  - Aged
MH  - Antigens, CD20/metabolism
MH  - CD5 Antigens/metabolism
MH  - Cell Transformation, Neoplastic/genetics/metabolism
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 14
MH  - *Chromosomes, Human, Pair 16
MH  - Female
MH  - Genetic Association Studies
MH  - Germinal Center/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Interferon Regulatory Factors/*genetics/*metabolism
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics/metabolism/*pathology
MH  - Models, Biological
MH  - Phenotype
MH  - *Translocation, Genetic
EDAT- 2013/04/12 06:00
MHDA- 2014/08/15 06:00
CRDT- 2013/04/12 06:00
PHST- 2013/04/12 06:00 [entrez]
PHST- 2013/04/12 06:00 [pubmed]
PHST- 2014/08/15 06:00 [medline]
AID - 10.3109/10428194.2013.793324 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2014 Jan;55(1):136-42. doi: 10.3109/10428194.2013.793324. Epub 
      2013 Jun 12.