PMID- 23573936
OWN - NLM
STAT- MEDLINE
DCOM- 20140303
LR  - 20231213
IS  - 1365-313X (Electronic)
IS  - 0960-7412 (Linking)
VI  - 75
IP  - 1
DP  - 2013 Jul
TI  - MIDGET connects COP1-dependent development with endoreduplication in Arabidopsis 
      thaliana.
PG  - 67-79
LID - 10.1111/tpj.12199 [doi]
AB  - In Arabidopsis thaliana, loss of CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1) function 
      leads to constitutive photomorphogenesis in the dark associated with inhibition 
      of endoreduplication in the hypocotyl, and a post-germination growth arrest. 
      MIDGET (MID), a component of the TOPOISOMERASE VI (TOPOVI) complex, is essential 
      for endoreduplication and genome integrity in A. thaliana. Here we show that MID 
      and COP1 interact in vitro and in vivo through the amino terminus of COP1. We 
      further demonstrate that MID supports sub-nuclear accumulation of COP1. The MID 
      protein is not degraded in a COP1-dependent fashion in darkness, and the 
      phenotypes of single and double mutants prove that MID is not a target of COP1 
      but rather a necessary factor for proper COP1 activity with respect to both, 
      control of COP1-dependent morphogenesis and regulation of endoreduplication. Our 
      data provide evidence for a functional connection between COP1 and the TOPOVI in 
      plants linking COP1-dependent development with the regulation of 
      endoreduplication.
CI  - (c) 2013 The Authors The Plant Journal (c) 2013 John Wiley & Sons Ltd.
FAU - Schrader, Andrea
AU  - Schrader A
AD  - University of Cologne, Botanical Institute III, Zuelpicher Str. 47b, 50674, 
      Koeln, Germany.
FAU - Welter, Bastian
AU  - Welter B
AD  - University of Cologne, Botanical Institute III, Zuelpicher Str. 47b, 50674, 
      Koeln, Germany.
FAU - Hulskamp, Martin
AU  - Hulskamp M
AD  - University of Cologne, Botanical Institute III, Zuelpicher Str. 47b, 50674, 
      Koeln, Germany.
FAU - Hoecker, Ute
AU  - Hoecker U
AD  - University of Cologne, Botanical Institute II, Zuelpicher Str. 47b, 50674, Koeln, 
      Germany.
FAU - Uhrig, Joachim F
AU  - Uhrig JF
AD  - University of Cologne, Botanical Institute III, Zuelpicher Str. 47b, 50674, 
      Koeln, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130507
PL  - England
TA  - Plant J
JT  - The Plant journal : for cell and molecular biology
JID - 9207397
RN  - 0 (Anthocyanins)
RN  - 0 (Arabidopsis Proteins)
RN  - 0 (Multienzyme Complexes)
RN  - 0 (Recombinant Fusion Proteins)
RN  - EC 2.3.2.27 (AT2G32950 protein, Arabidopsis)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 5.99.1.- (DNA Topoisomerase IV)
SB  - IM
MH  - Anthocyanins/metabolism
MH  - Arabidopsis/*genetics/growth & development/metabolism/ultrastructure
MH  - Arabidopsis Proteins/*genetics/metabolism
MH  - DNA Topoisomerase IV/*genetics/metabolism
MH  - Darkness
MH  - Endoreduplication/*genetics
MH  - *Gene Expression Regulation, Plant
MH  - Germination
MH  - Hypocotyl/genetics/growth & development/metabolism/ultrastructure
MH  - Multienzyme Complexes
MH  - Mutation
MH  - Onions/genetics/metabolism
MH  - Phenotype
MH  - Plant Leaves/genetics/growth & development/metabolism/ultrastructure
MH  - Plants, Genetically Modified
MH  - Ploidies
MH  - Recombinant Fusion Proteins
MH  - Seedlings/genetics/growth & development/metabolism/ultrastructure
MH  - Nicotiana/genetics/metabolism
MH  - Two-Hybrid System Techniques
MH  - Ubiquitin-Protein Ligases/*genetics/metabolism
EDAT- 2013/04/12 06:00
MHDA- 2014/03/04 06:00
CRDT- 2013/04/12 06:00
PHST- 2012/12/18 00:00 [received]
PHST- 2013/04/02 00:00 [revised]
PHST- 2013/04/07 00:00 [accepted]
PHST- 2013/04/12 06:00 [entrez]
PHST- 2013/04/12 06:00 [pubmed]
PHST- 2014/03/04 06:00 [medline]
AID - 10.1111/tpj.12199 [doi]
PST - ppublish
SO  - Plant J. 2013 Jul;75(1):67-79. doi: 10.1111/tpj.12199. Epub 2013 May 7.