PMID- 23574520
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20190907
IS  - 1873-4294 (Electronic)
IS  - 1568-0266 (Linking)
VI  - 13
IP  - 6
DP  - 2013
TI  - Antigen presentation by dendritic cells in rheumatoid arthritis.
PG  - 712-9
AB  - Rheumatoid Arthritis (RA) is a chronic autoimmune inflammatory disease that 
      affects largely synovial joints. It has been postulated that activated 
      autoreactive CD4 T cells play a key role in triggering and/or maintaining the 
      chronic inflammatory process in RA. Dendritic cells (DCs) are antigen-presenting 
      cells that activate cognate clonal CD4 T cells in the lymph nodes. The activation 
      process involves the formation of a molecular structure at the DC-CD4 T cell 
      contact zone called immunological synapse (IS). In RA, the synovium, a thin layer 
      of tissue below the capsule in the joints, shows a massive infiltration of DCs 
      and CD4 T cells. Subjects bearing HLA-DRB1 alleles of the Major 
      Histocompatibility Complex II gene displaying a motif called RA "shared epitope 
      (SE)", have an enhanced susceptibility to suffer RA. Interestingly, the 
      SE-containing HLA-DRB1 molecules display a pocket with a high affinity for 
      citrullinated antigens, which are found at higher levels in subjects prone to 
      develop RA. Thus, it is possible that the DCs of susceptible individuals may form 
      IS with particular features that may present citrullinated peptides to 
      autorreactive naive CD4 T clones that, after being activated, contribute to the 
      initiation or development of the disease. Herein I put forward a model of RA 
      initiation based on current information on the immune response and RA.
FAU - Rodriguez-Fernandez, Jose Luis
AU  - Rodriguez-Fernandez JL
AD  - CIB/CSIC (Centro de Investigaciones Biologicas, Consejo Superior de 
      Investigaciones Cientificas), C/ Ramiro de Maeztu, 9, 28040 Madrid, Spain. 
      rodrifer@cib.csic.es
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Top Med Chem
JT  - Current topics in medicinal chemistry
JID - 101119673
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Arthritis, Rheumatoid/*immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
EDAT- 2013/04/12 06:00
MHDA- 2014/01/15 06:00
CRDT- 2013/04/12 06:00
PHST- 2012/09/25 00:00 [received]
PHST- 2012/10/19 00:00 [revised]
PHST- 2012/11/05 00:00 [accepted]
PHST- 2013/04/12 06:00 [entrez]
PHST- 2013/04/12 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - CTMC-EPUB-20130409-4 [pii]
AID - 10.2174/1568026611313060004 [doi]
PST - ppublish
SO  - Curr Top Med Chem. 2013;13(6):712-9. doi: 10.2174/1568026611313060004.