PMID- 23574728
OWN - NLM
STAT- MEDLINE
DCOM- 20131210
LR  - 20211021
IS  - 1746-6148 (Electronic)
IS  - 1746-6148 (Linking)
VI  - 9
DP  - 2013 Apr 10
TI  - The ESR1 gene is associated with risk for canine mammary tumours.
PG  - 69
LID - 10.1186/1746-6148-9-69 [doi]
AB  - BACKGROUND: The limited within-breed genetic heterogeneity and an enrichment of 
      disease-predisposing alleles have made the dog a very suitable model for the 
      identification of genes associated with risk for specific diseases. Canine 
      mammary cancer is an example of such a disease. However, the underlying inherited 
      risk factors for canine mammary tumours (CMTs) are still largely unknown. In this 
      study, 52 single nucleotide polymorphisms (SNPs) in ten human cancer-associated 
      genes were genotyped in two different datasets in order to identify genes/alleles 
      associated with the development of CMTs. The first dataset consisted of English 
      Springer Spaniel (ESS) CMT cases and controls. ESS is a dog breed known to be at 
      increased risk of developing CMTs. In the second dataset, dogs from breeds known 
      to have a high frequency of CMTs were compared to dogs from breeds with a lower 
      occurrence of these tumours. RESULTS: We found significant associations to CMT 
      for SNPs and haplotypes in the estrogen receptor 1 (ESR1) gene in the ESS 
      material (best PBonf = 0.021). A large number of SNPs, among them several SNPs in 
      ESR1, showed significantly different allele frequencies between the high and low 
      risk breed groups (best PBonf = 8.8E-32, best PBPerm = 0.076). CONCLUSIONS: The 
      identification of CMT-associated SNPs in ESR1 in two independent datasets 
      suggests that this gene might be involved in CMT development. These findings also 
      support that CMT may serve as a good model for human breast cancer research.
FAU - Borge, Kaja Sverdrup
AU  - Borge KS
AD  - Section of Genetics, Department of Basic Sciences and Aquatic Medicine, Norwegian 
      School of Veterinary Science, P,O Box 8146 Dep,, 0033 Oslo, Norway. 
      KajaSverdrup.Borge@nvh.no
FAU - Melin, Malin
AU  - Melin M
FAU - Rivera, Patricio
AU  - Rivera P
FAU - Thoresen, Stein Istre
AU  - Thoresen SI
FAU - Webster, Matthew Thomas
AU  - Webster MT
FAU - von Euler, Henrik
AU  - von Euler H
FAU - Lindblad-Toh, Kerstin
AU  - Lindblad-Toh K
FAU - Lingaas, Frode
AU  - Lingaas F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130410
PL  - England
TA  - BMC Vet Res
JT  - BMC veterinary research
JID - 101249759
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Dog Diseases/*genetics
MH  - Dogs
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Genetic Association Studies/veterinary
MH  - Genetic Predisposition to Disease
MH  - Haplotypes/genetics
MH  - Mammary Neoplasms, Animal/*genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Risk Factors
MH  - Sequence Alignment/veterinary
PMC - PMC3637093
EDAT- 2013/04/12 06:00
MHDA- 2013/12/16 06:00
PMCR- 2013/04/10
CRDT- 2013/04/12 06:00
PHST- 2012/10/29 00:00 [received]
PHST- 2013/03/25 00:00 [accepted]
PHST- 2013/04/12 06:00 [entrez]
PHST- 2013/04/12 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2013/04/10 00:00 [pmc-release]
AID - 1746-6148-9-69 [pii]
AID - 10.1186/1746-6148-9-69 [doi]
PST - epublish
SO  - BMC Vet Res. 2013 Apr 10;9:69. doi: 10.1186/1746-6148-9-69.