PMID- 23575622
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20220801
IS  - 2210-7711 (Electronic)
VI  - 35
IP  - 3
DP  - 2013 Jun
TI  - HLA typing in Brazilian boys with aromatic antiepileptic drug-induced DRESS.
PG  - 319-22
LID - 10.1007/s11096-013-9770-3 [doi]
AB  - CASES DESCRIPTION: We report two cases of drug rash with eosinophilia and 
      systemic symptoms (DRESS) associated with the use of carbamazepine and phenytoin 
      in Brazilian boys tested for human leukocyte antigen (HLA) class I and II 
      alleles. The clinical manifestations were similar: a maculopapular eruption 
      progressing to exfoliative erythroderma, fever, and lymphadenopathy. 
      Leukocytosis, atypical lymphocytes, and liver injury were also observed. 
      Assessment of causality using the Naranjo algorithm established a "probable" 
      relationship (score 6) in both cases. Case 1 patient presented the following 
      results of HLA typing: HLA-A*02,29 B*44,50 C*06,16 DRB1*01,07 DQA1*01,02. Case 2 
      patient presented the following results of HLA typing: HLAA*23,24 B*39,53 C*04,07 
      DRB1*04,08 DQA1*03,05 DQB1*03,03. CONCLUSION: Neither of the cases reported here 
      presented HLA typing similar to that strongly associated with the occurrence of 
      DRESS in Asian or European patients.
FAU - Gaeti, Walderez Penteado
AU  - Gaeti WP
AD  - Department of Pharmacology and Therapeutics, State University of Maringa, Avenue 
      Colombo 5790, Maringa, PR 87020-290, Brazil.
FAU - Obreli-Neto, Paulo Roque
AU  - Obreli-Neto PR
FAU - Moliterno, Ricardo A
AU  - Moliterno RA
FAU - Schiavon, Gina Bressan
AU  - Schiavon GB
FAU - Cuman, Roberto Kenji Nakamura
AU  - Cuman RK
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130411
PL  - Netherlands
TA  - Int J Clin Pharm
JT  - International journal of clinical pharmacy
JID - 101554912
RN  - 0 (Anticonvulsants)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 33CM23913M (Carbamazepine)
RN  - 6158TKW0C5 (Phenytoin)
SB  - IM
MH  - Alleles
MH  - Anticonvulsants/*adverse effects/therapeutic use
MH  - Brazil
MH  - Carbamazepine/*adverse effects/therapeutic use
MH  - Child
MH  - Drug Eruptions/*etiology/immunology
MH  - Eosinophilia/chemically induced/immunology
MH  - Epilepsy/drug therapy
MH  - Histocompatibility Antigens Class I/immunology
MH  - Histocompatibility Antigens Class II/immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Male
MH  - Phenytoin/*adverse effects/therapeutic use
EDAT- 2013/04/12 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/04/12 06:00
PHST- 2012/12/30 00:00 [received]
PHST- 2013/04/01 00:00 [accepted]
PHST- 2013/04/12 06:00 [entrez]
PHST- 2013/04/12 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1007/s11096-013-9770-3 [doi]
PST - ppublish
SO  - Int J Clin Pharm. 2013 Jun;35(3):319-22. doi: 10.1007/s11096-013-9770-3. Epub 
      2013 Apr 11.