PMID- 23575842
OWN - NLM
STAT- MEDLINE
DCOM- 20130605
LR  - 20211021
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 33
IP  - 15
DP  - 2013 Apr 10
TI  - Top-down regulation of default mode activity in spatial visual attention.
PG  - 6444-53
LID - 10.1523/JNEUROSCI.4939-12.2013 [doi]
AB  - Dorsal anterior cingulate and bilateral anterior insula form a task control 
      network (TCN) whose primary function includes initiating and maintaining 
      task-level cognitive set and exerting top-down regulation of sensorimotor 
      processing. The default mode network (DMN), comprising an anatomically distinct 
      set of cortical areas, mediates introspection and self-referential processes. 
      Resting-state data show that TCN and DMN interact. The functional ramifications 
      of their interaction remain elusive. Recording fMRI data from human subjects 
      performing a visual spatial attention task and correlating Granger causal 
      influences with behavioral performance and blood oxygen level-dependent (BOLD) 
      activity we report three main findings. First, causal influences from TCN to DMN, 
      i.e., TCN --> DMN, are positively correlated with behavioral performance. Second, 
      causal influences from DMN to TCN, i.e., DMN --> TCN, are negatively correlated 
      with behavioral performance. Third, stronger DMN --> TCN are associated with less 
      elevated BOLD activity in TCN, whereas the relationship between TCN --> DMN and DMN 
      BOLD activity is unsystematic. These results suggest that, during visual spatial 
      attention, top-down signals from TCN to DMN regulate the activity in DMN to 
      enhance behavioral performance, whereas signals from DMN to TCN, acting possibly 
      as internal noise, interfere with task control, leading to degraded behavioral 
      performance.
FAU - Wen, Xiaotong
AU  - Wen X
AD  - J Crayton Pruitt Family Department of Biomedical Engineering and Department of 
      Psychiatry and McKnight Brain Institute, University of Florida, Gainesville, 
      Florida 32611, USA.
FAU - Liu, Yijun
AU  - Liu Y
FAU - Yao, Li
AU  - Yao L
FAU - Ding, Mingzhou
AU  - Ding M
LA  - eng
GR  - R01 MH097320/MH/NIMH NIH HHS/United States
GR  - MH097320/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Attention/*physiology
MH  - Brain Mapping/methods/*psychology
MH  - Cerebral Cortex/*physiology
MH  - Gyrus Cinguli/*physiology
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/methods/psychology
MH  - Models, Neurological
MH  - Neural Pathways/physiology
MH  - Psychomotor Performance/physiology
PMC - PMC3670184
MID - NIHMS466285
EDAT- 2013/04/12 06:00
MHDA- 2013/06/06 06:00
PMCR- 2013/10/10
CRDT- 2013/04/12 06:00
PHST- 2013/04/12 06:00 [entrez]
PHST- 2013/04/12 06:00 [pubmed]
PHST- 2013/06/06 06:00 [medline]
PHST- 2013/10/10 00:00 [pmc-release]
AID - 33/15/6444 [pii]
AID - 4939-12 [pii]
AID - 10.1523/JNEUROSCI.4939-12.2013 [doi]
PST - ppublish
SO  - J Neurosci. 2013 Apr 10;33(15):6444-53. doi: 10.1523/JNEUROSCI.4939-12.2013.