PMID- 23576494
OWN - NLM
STAT- MEDLINE
DCOM- 20140402
LR  - 20220408
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
VI  - 29
IP  - 6
DP  - 2013 Sep
TI  - Cross-sectional and longitudinal associations between insulin-like growth factor 
      I and metabolic syndrome: a general population study in German adults.
PG  - 452-62
LID - 10.1002/dmrr.2412 [doi]
AB  - BACKGROUND: A previous study showed an inverse association between the 
      insulin-like growth factor I (IGF-I) and the risk of impaired glucose tolerance 
      or diabetes mellitus. Moreover, myocardial infarction patients with high baseline 
      IGF-I levels had a lower risk of diabetes mellitus. These data suggested a 
      protective effect of IGF-I against the development of metabolic syndrome. 
      However, there are no longitudinal data regarding IGF-I and metabolic syndrome. 
      The aim of the present study was to investigate the longitudinal association 
      between IGF-I and metabolic syndrome. METHODS: Data from the population-based 
      Study of Health in Pomerania, Germany, were used for cross-sectional (n = 3903) 
      and longitudinal (n = 2143) analyses (5-year follow-up). Metabolic syndrome was 
      defined by three or more of the following five components: abdominal obesity, 
      elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated 
      blood pressure and elevated nonfasting glucose. Serum IGF-I and IGF binding 
      protein 3 (IGFBP-3) were determined by chemiluminescence immunoassays. Logistic 
      and Poisson regression analyses were performed to determine associations. 
      RESULTS: In cross-sectional analyses high IGFBP-3 as well as high and low 
      IGF-I/IGFBP-3 ratio levels were associated with prevalent metabolic syndrome. In 
      longitudinal analyses, the direction of the relation changed: men but not women 
      with high IGF-I or IGF-I/IGFBP-3 ratio levels had an increased, whereas men with 
      low levels had a decreased risk of incident metabolic syndrome. CONCLUSION: In 
      concordance with previous studies, our cross-sectional analyses showed a relation 
      between low IGF-I/IGFBP-3 ratio and the prevalence of metabolic syndrome. In 
      contrast, the longitudinal analyses indicated that a high IGF-I level was a risk 
      marker for incident metabolic syndrome.
CI  - Copyright (c) 2013 John Wiley & Sons, Ltd.
FAU - Friedrich, Nele
AU  - Friedrich N
AD  - Institute of Clinical Chemistry and Laboratory Medicine, University Medicine 
      Greifswald, Ferdinand-Sauerbruch-Strasse NK, D-17475, Greifswald, Germany.
FAU - Nauck, Matthias
AU  - Nauck M
FAU - Schipf, Sabine
AU  - Schipf S
FAU - Volzke, Henry
AU  - Volzke H
FAU - Brabant, Georg
AU  - Brabant G
FAU - Wallaschofski, Henri
AU  - Wallaschofski H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Germany/epidemiology
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Longitudinal Studies
MH  - Male
MH  - Metabolic Syndrome/blood/*epidemiology
MH  - Middle Aged
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - IGF-I
OT  - IGFBP-3
OT  - Study of Health in Pomerania (SHIP)
OT  - metabolic syndrome
OT  - type 2 diabetes mellitus
EDAT- 2013/04/12 06:00
MHDA- 2014/04/03 06:00
CRDT- 2013/04/12 06:00
PHST- 2012/11/13 00:00 [received]
PHST- 2013/02/22 00:00 [revised]
PHST- 2013/03/08 00:00 [accepted]
PHST- 2013/04/12 06:00 [entrez]
PHST- 2013/04/12 06:00 [pubmed]
PHST- 2014/04/03 06:00 [medline]
AID - 10.1002/dmrr.2412 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2013 Sep;29(6):452-62. doi: 10.1002/dmrr.2412.