PMID- 23578391
OWN - NLM
STAT- MEDLINE
DCOM- 20130813
LR  - 20191210
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Linking)
VI  - 308
DP  - 2013 Jun 7
TI  - Perinatal exposure to BDE-99 causes learning disorders and decreases serum 
      thyroid hormone levels and BDNF gene expression in hippocampus in rat offspring.
PG  - 122-8
LID - S0300-483X(13)00072-3 [pii]
LID - 10.1016/j.tox.2013.03.010 [doi]
AB  - Exposure of pregnant women to polybrominated diphenyl ethers (PBDEs) may mean 
      serious health risks. The main goal of the present study was to examine the 
      neurobehavioral changes in rat offspring that were perinatally exposed to one of 
      the most prevalent PBDEs congeners found in humans, 2,2',4,4',5-pentaBDE 
      (BDE-99). Rat dams were exposed to 0, 1 and 2mg/kg/day of BDE-99 from gestation 
      day 6 to post-natal day 21. When pups were weaning, cortex and hippocampal gene 
      expressions of brain-derived neurotrophic factor (BDNF) of the different isoforms 
      of the thyroid hormone (TH) receptors (TRs) were evaluated. Serum TH levels were 
      also determined. The remaining pups were assessed by neurobehavioral testing for 
      learning and memory function. The results showed that maternal transference of 
      BDE-99 produced a delay in the spatial learning task in the water maze test. 
      Moreover, the open-field test revealed a significant dose-response anxiolytic 
      effect. It was also found that the serum levels of triiodothyronine (T3), 
      tetraiiodothyronine (T4) and free-T4 (FT4) decreased. Although no effect on the 
      gene expression of the different isoforms of TRs was observed, the expression of 
      the TH-mediated gene BDNF was down-regulated in the hippocampus. These results 
      indicate a clear signal disruption of TH and reinforce previous studies in which 
      neurotoxic effects of PBDEs in animal research were observed at levels comparable 
      to those found in humans.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Blanco, Jordi
AU  - Blanco J
AD  - Laboratory of Toxicology and Envirsonmental Health, School of Medicine, IISPV, 
      Universitat Rovira i Virgili, Sant Llorens 21, 43201 Reus, Spain.
FAU - Mulero, Miquel
AU  - Mulero M
FAU - Heredia, Luis
AU  - Heredia L
FAU - Pujol, Andreu
AU  - Pujol A
FAU - Domingo, Jose L
AU  - Domingo JL
FAU - Sanchez, Domenec J
AU  - Sanchez DJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130408
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (2,2',4,4',5-brominated diphenyl ether)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Thyroid Hormones)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/antagonists & inhibitors/*biosynthesis
MH  - Down-Regulation/drug effects
MH  - Female
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - Halogenated Diphenyl Ethers/*toxicity
MH  - Hippocampus/drug effects/*metabolism
MH  - Learning Disabilities/*blood/chemically induced
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*blood/chemically induced
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Thyroid Hormones/*blood
EDAT- 2013/04/13 06:00
MHDA- 2013/08/14 06:00
CRDT- 2013/04/13 06:00
PHST- 2013/03/13 00:00 [received]
PHST- 2013/03/25 00:00 [revised]
PHST- 2013/03/25 00:00 [accepted]
PHST- 2013/04/13 06:00 [entrez]
PHST- 2013/04/13 06:00 [pubmed]
PHST- 2013/08/14 06:00 [medline]
AID - S0300-483X(13)00072-3 [pii]
AID - 10.1016/j.tox.2013.03.010 [doi]
PST - ppublish
SO  - Toxicology. 2013 Jun 7;308:122-8. doi: 10.1016/j.tox.2013.03.010. Epub 2013 Apr 
      8.