PMID- 23578780 OWN - NLM STAT- MEDLINE DCOM- 20150416 LR - 20191210 IS - 1578-1267 (Electronic) IS - 0301-0546 (Linking) VI - 42 IP - 3 DP - 2014 May-Jun TI - Clinical and immunological features of common variable immunodeficiency in Mexican patients. PG - 235-40 LID - S0301-0546(13)00055-4 [pii] LID - 10.1016/j.aller.2013.01.007 [doi] AB - BACKGROUND: Common variable immunodeficiency (CVID) is characterised by hypogammaglobulinaemia and a broad clinical spectrum, mainly showing recurrent bacterial infections accompanied sometimes by increased susceptibility to chronic lung disease, autoimmunity, and neoplastic diseases. OBJECTIVES: To evaluate the clinical and immunological characteristics of patients with CVID in Mexico. METHODS: This is a retrospective analysis of 43 patients with CVID from the Immunology Division of seven different reference centres in Mexico. Patients were diagnosed according to the diagnostic criteria of the European Society for Immunodeficiency Diseases. We collected demographics, clinical and immunological data from each patient and a statistical analysis was performed. RESULTS: There were 23 (53.5%) male and 20 (46.5%) female patients. Median age at onset of disease was 13.7 years, and median age at diagnosis was 19 years. Average delay in diagnosis was 12.5 years. The median total serum levels of IgG, IgM, and IgA at diagnosis were 175, 18, and 17.8mg/dL, respectively. The mean percentage of CD19+ B cells was 8.15%. Sinusitis (83%), pneumonia (83%), gastrointestinal infection (70%), and acute otitis media (49%) were the most common manifestations. Bronchiectasis was present in 51% of the patients, 44% manifested non-infectious chronic diarrhoea, and 70% experienced weight loss. Autoimmunity was present in 23% of the patients; haemolytic anaemia and autoimmune thrombocytopenic purpura were the most common presentations. Allergy was present in 30.2% of patients, with allergic rhinitis and asthma being the most frequent types. Two patients developed malignancy. All the patients received Intravenous immunoglobulin (IVIG) as a fundamental part of the treatment at a mean dose of 408mg/kg. CONCLUSION: This is the first cohort of CVID reported in Mexico We found that infection diseases were the most frequent presentations at onset. Moreover, patients had an average diagnosis delay of twelve years and thus a major prevalence of bronchiectasis. We suggest performing an extended analysis of patients with CVID patients in other Latin American countries. CI - Copyright (c) 2012 SEICAP. Published by Elsevier Espana. All rights reserved. FAU - Ramirez-Vargas, N AU - Ramirez-Vargas N AD - Unidad de Investigacion en Inmunodeficiencias, Instituto Nacional de Pediatria, Mexico City, Mexico. FAU - Arablin-Oropeza, S E AU - Arablin-Oropeza SE AD - Unidad de Investigacion en Inmunodeficiencias, Instituto Nacional de Pediatria, Mexico City, Mexico. FAU - Mojica-Martinez, D AU - Mojica-Martinez D AD - Centro Medico Nacional, La Raza, IMSS, Mexico City, Mexico. FAU - Yamazaki-Nakashimada, M A AU - Yamazaki-Nakashimada MA AD - Servicio de Inmunologia, Instituto Nacional de Pediatria, Mexico City, Mexico. FAU - de la Luz Garcia-Cruz, M AU - de la Luz Garcia-Cruz M AD - Departamento de Alergia, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico. FAU - Teran-Juarez, L M AU - Teran-Juarez LM AD - Departamento de Alergia, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico. FAU - Cortes-Grimaldo, R M AU - Cortes-Grimaldo RM AD - Clinica 180 del IMSS, Guadalajara, Mexico. FAU - Torres-Lozano, C AU - Torres-Lozano C AD - Hospital de Especialidades del Centro Medico Nacional de Occidente, IMSS, Guadalajara, Mexico. FAU - Madrigal-Beas, I AU - Madrigal-Beas I AD - Hospital de Especialidades del Centro Medico Nacional de Occidente, IMSS, Guadalajara, Mexico. FAU - Ortega-Cisneros, M AU - Ortega-Cisneros M AD - Hospital de Especialidades del Centro Medico Nacional de Occidente, IMSS, Guadalajara, Mexico. FAU - Vargas-Camano, M E AU - Vargas-Camano ME AD - Centro Medico Nacional 20 de Noviembre, ISSSTE, Mexico City, Mexico. FAU - Staines-Boone, T AU - Staines-Boone T AD - Unidad Medica de Alta Especialidad #25 IMSS, Monterrey N.L., Mexico. FAU - Pietropaolo-Cienfuegos, D AU - Pietropaolo-Cienfuegos D AD - Servicio de Alergia e Inmunologia, Hospital Infantil de Mexico, Mexico City, Mexico. FAU - Berron-Ruiz, L AU - Berron-Ruiz L AD - Unidad de Investigacion en Inmunodeficiencias, Instituto Nacional de Pediatria, Mexico City, Mexico. FAU - Espinosa-Rosales, F J AU - Espinosa-Rosales FJ AD - Unidad de Investigacion en Inmunodeficiencias, Instituto Nacional de Pediatria, Mexico City, Mexico; Direccion de investigacion, Instituto Nacional de Pediatria, Mexico City, Mexico. FAU - Guevara-Cruz, M AU - Guevara-Cruz M AD - Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico. FAU - Blancas-Galicia, L AU - Blancas-Galicia L AD - Unidad de Investigacion en Inmunodeficiencias, Instituto Nacional de Pediatria, Mexico City, Mexico. Electronic address: lbg73_2000@yahoo.com. LA - eng PT - Journal Article DEP - 20130408 PL - Singapore TA - Allergol Immunopathol (Madr) JT - Allergologia et immunopathologia JID - 0370073 RN - 0 (Antigens, CD19) RN - 0 (Immunoglobulins) RN - 0 (Immunoglobulins, Intravenous) SB - IM MH - Adolescent MH - Adult MH - Antigens, CD19/metabolism MH - Asthma/*immunology MH - Autoimmunity MH - B-Lymphocytes/*immunology MH - Bronchiectasis/*immunology MH - Child MH - Cohort Studies MH - Common Variable Immunodeficiency/*immunology/physiopathology/therapy MH - Female MH - Humans MH - Immunoglobulins/blood MH - Immunoglobulins, Intravenous/therapeutic use MH - Infections/*immunology MH - Male MH - Mexico MH - Retrospective Studies MH - Young Adult OTO - NOTNLM OT - Common variable immunodeficiency OT - Humoral deficiency OT - Primary antibody deficiency OT - Primary immunodeficiency EDAT- 2013/04/13 06:00 MHDA- 2015/04/17 06:00 CRDT- 2013/04/13 06:00 PHST- 2012/09/28 00:00 [received] PHST- 2013/01/09 00:00 [revised] PHST- 2013/01/19 00:00 [accepted] PHST- 2013/04/13 06:00 [entrez] PHST- 2013/04/13 06:00 [pubmed] PHST- 2015/04/17 06:00 [medline] AID - S0301-0546(13)00055-4 [pii] AID - 10.1016/j.aller.2013.01.007 [doi] PST - ppublish SO - Allergol Immunopathol (Madr). 2014 May-Jun;42(3):235-40. doi: 10.1016/j.aller.2013.01.007. Epub 2013 Apr 8.