PMID- 23578839
OWN - NLM
STAT- MEDLINE
DCOM- 20140124
LR  - 20191210
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 103
DP  - 2013 Jul
TI  - Impaired fear extinction learning in adult heterozygous BDNF knock-out mice.
PG  - 34-8
LID - S1074-7427(13)00040-3 [pii]
LID - 10.1016/j.nlm.2013.03.003 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a crucial regulator of 
      neuroplasticity, which underlies learning and memory processes in different brain 
      areas. To investigate the role of BDNF in the extinction of amygdala-dependent 
      cued fear memories, we analyzed fear extinction learning in heterozygous BDNF 
      knock-out mice, which possess a reduction of endogenous BDNF protein levels to 
      ~50% of wild-type animals. Since BDNF expression has been shown to decline with 
      aging of animals, we tested the performance in extinction learning of these mice 
      at 2 months (young adults) and 7 months (older adults) of age. The present study 
      shows that older adult heterozygous BDNF knock-out mice, which have a chronic 50% 
      lack of BDNF, also possess a deficit in the acquisition of extinction memory, 
      while extinction learning remains unaffected in young adult heterozygous BDNF 
      knock-out mice. This deficit in extinction learning is accompanied by a reduction 
      of BDNF protein in the hippocampus, amygdala and the prefrontal cortex.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Psotta, Laura
AU  - Psotta L
AD  - Institute of Physiology, Medical Faculty, Otto-von-Guericke-University Magdeburg, 
      Leipziger Str. 44, 39120 Magdeburg, Germany.
FAU - Lessmann, Volkmar
AU  - Lessmann V
FAU - Endres, Thomas
AU  - Endres T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130408
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Conditioning, Psychological/*physiology
MH  - Extinction, Psychological/*physiology
MH  - Fear/*physiology
MH  - Heterozygote
MH  - Mice
MH  - Mice, Knockout
EDAT- 2013/04/13 06:00
MHDA- 2014/01/25 06:00
CRDT- 2013/04/13 06:00
PHST- 2012/10/29 00:00 [received]
PHST- 2013/03/25 00:00 [revised]
PHST- 2013/03/25 00:00 [accepted]
PHST- 2013/04/13 06:00 [entrez]
PHST- 2013/04/13 06:00 [pubmed]
PHST- 2014/01/25 06:00 [medline]
AID - S1074-7427(13)00040-3 [pii]
AID - 10.1016/j.nlm.2013.03.003 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2013 Jul;103:34-8. doi: 10.1016/j.nlm.2013.03.003. Epub 2013 
      Apr 8.