PMID- 23578862
OWN - NLM
STAT- MEDLINE
DCOM- 20131029
LR  - 20181202
IS  - 1471-6771 (Electronic)
IS  - 0007-0912 (Linking)
VI  - 111
IP  - 3
DP  - 2013 Sep
TI  - Feasibility and safety of xenon compared with sevoflurane anaesthesia in coronary 
      surgical patients: a randomized controlled pilot study.
PG  - 406-16
LID - 10.1093/bja/aet072 [doi]
AB  - BACKGROUND: To date, only limited data exist about the use of xenon as an 
      anaesthetic agent in patients undergoing cardiac surgery. The favourable cardio- 
      and neuroprotective properties of xenon might attenuate postoperative 
      complications, improve outcome, and reduce the incidence of delirium. Thus, the 
      aims of this study were to investigate the feasibility and safety of balanced 
      xenon anaesthesia in patients undergoing cardiac surgery and to gather pilot data 
      for a future randomized multicentre study. METHODS: Thirty patients undergoing 
      elective coronary artery bypass grafting were enrolled in this randomized, 
      single-blind controlled trial. They were randomized to receive balanced general 
      anaesthesia with either xenon (45-50 vol%) or sevoflurane (1-1.4 vol%). The 
      primary outcome was the occurrence of adverse events (AEs). Secondary outcome 
      parameters were feasibility criteria (bispectral index, perioperative 
      haemodynamic, and respiratory profile) and safety parameters (dosage of study 
      treatments, renal function, intraoperative blood loss, need for inotropic 
      support, regional cerebral tissue oxygenation). Furthermore, at predefined time 
      points, systemic and pulmonary haemodynamics were assessed by the use of a 
      pulmonary artery catheter. RESULTS: There were no patient characteristic 
      differences between the groups. Patients undergoing xenon anaesthesia did not 
      differ with respect to the incidence of AE (6 vs 8, P=0.464) compared with the 
      sevoflurane group. No differences were detected regarding secondary feasibility 
      and safety criteria. The haemodynamic and respiratory profile was comparable 
      between the treatment groups. CONCLUSIONS: Balanced xenon anaesthesia is feasible 
      and safe compared with sevoflurane anaesthesia in patients undergoing coronary 
      artery bypass surgery. Acronym CARDIAX: A pre- and post-coronary artery bypass 
      graft implantation disposed application of xenon. Clinical trial registration 
      ClinicalTrials.gov: NCT01285271; EudraCT-number: 2010-023942-63. Approved by the 
      ethics committee 'Ethik-Kommission an der Medizinischen Fakultat der 
      Rheinisch-Westfalischen Technischen Hochschule Aachen (RWTH Aachen)': EK-218/10.
FAU - Stoppe, C
AU  - Stoppe C
AD  - Department of Anesthesiology, RWTH University Hospital, Pauwelsstr. 30, D-52074 
      Aachen, Germany.
FAU - Fahlenkamp, A V
AU  - Fahlenkamp AV
FAU - Rex, S
AU  - Rex S
FAU - Veeck, N C
AU  - Veeck NC
FAU - Gozdowsky, S C
AU  - Gozdowsky SC
FAU - Schalte, G
AU  - Schalte G
FAU - Autschbach, R
AU  - Autschbach R
FAU - Rossaint, R
AU  - Rossaint R
FAU - Coburn, M
AU  - Coburn M
LA  - eng
SI  - ClinicalTrials.gov/NCT01285271
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130411
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - 3H3U766W84 (Xenon)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anesthetics, Inhalation/*adverse effects
MH  - Coronary Artery Bypass/*methods
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Methyl Ethers/*adverse effects
MH  - Middle Aged
MH  - Pilot Projects
MH  - Postoperative Complications/*chemically induced/prevention & control
MH  - Prospective Studies
MH  - Sevoflurane
MH  - Single-Blind Method
MH  - Xenon/*adverse effects
OTO - NOTNLM
OT  - anaesthesia
OT  - anaesthetic gases
OT  - cardiac surgery, haemodynamic, xenon
EDAT- 2013/04/13 06:00
MHDA- 2013/10/30 06:00
CRDT- 2013/04/13 06:00
PHST- 2013/04/13 06:00 [entrez]
PHST- 2013/04/13 06:00 [pubmed]
PHST- 2013/10/30 06:00 [medline]
AID - S0007-0912(17)32398-X [pii]
AID - 10.1093/bja/aet072 [doi]
PST - ppublish
SO  - Br J Anaesth. 2013 Sep;111(3):406-16. doi: 10.1093/bja/aet072. Epub 2013 Apr 11.