PMID- 23578995
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20130617
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Linking)
VI  - 32
DP  - 2013 Aug
TI  - The stimulation of dendritic cells by amyloid beta 1-42 reduces BDNF production 
      in Alzheimer's disease patients.
PG  - 29-32
LID - S0889-1591(13)00140-2 [pii]
LID - 10.1016/j.bbi.2013.04.001 [doi]
AB  - Dendritic cells (DCs), the main actors of immune responses and inflammation, may 
      play a role in Alzheimer's disease (AD). Recent studies demonstrate that 
      monocyte-derived DCs (MDDCs), generated in vitro in the presence of amyloid beta1-42 
      peptide (Abeta1-42), show a functional alteration and an increased production of 
      inflammatory molecules. Accordingly, MDDCs from AD patients show a more 
      pronounced pro-inflammatory profile than DCs obtained from control subjects. In 
      this study, we aimed at further investigating DC role in AD. Thus, we analyzed 
      the in vitro effect of Abeta1-42 treatment on already differentiated DCs from AD 
      patients, as compared to control subjects. We found that Abeta1-42 significantly 
      decreases the expression of brain-derived neurotrophic factor (BDNF) in DCs 
      derived from AD patients but not from control subjects. Thus, possibly due to 
      their Abeta-induced reduction of neurotrophic support to neurons, DCs from AD 
      patients might contribute to brain damage by playing a part in Abeta-dependent 
      neuronal toxicity.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Ciaramella, Antonio
AU  - Ciaramella A
AD  - Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, 
      Via Ardeatina 306, 00179 Rome, Italy. a.ciaramella@hsantalucia.it
FAU - Salani, Francesca
AU  - Salani F
FAU - Bizzoni, Federica
AU  - Bizzoni F
FAU - Orfei, Maria Donata
AU  - Orfei MD
FAU - Langella, Roberto
AU  - Langella R
FAU - Angelucci, Francesco
AU  - Angelucci F
FAU - Spalletta, Gianfranco
AU  - Spalletta G
FAU - Taddei, Anna Rita
AU  - Taddei AR
FAU - Caltagirone, Carlo
AU  - Caltagirone C
FAU - Bossu, Paola
AU  - Bossu P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130408
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*metabolism
MH  - Amyloid beta-Peptides/*pharmacology
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*drug effects/metabolism
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - Peptide Fragments/*pharmacology
MH  - Phagocytosis/physiology
MH  - Stimulation, Chemical
MH  - T-Lymphocytes/physiology
EDAT- 2013/04/13 06:00
MHDA- 2014/01/28 06:00
CRDT- 2013/04/13 06:00
PHST- 2012/06/05 00:00 [received]
PHST- 2013/03/12 00:00 [revised]
PHST- 2013/04/01 00:00 [accepted]
PHST- 2013/04/13 06:00 [entrez]
PHST- 2013/04/13 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
AID - S0889-1591(13)00140-2 [pii]
AID - 10.1016/j.bbi.2013.04.001 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2013 Aug;32:29-32. doi: 10.1016/j.bbi.2013.04.001. Epub 2013 
      Apr 8.