PMID- 23579620
OWN - NLM
STAT- MEDLINE
DCOM- 20140117
LR  - 20161125
IS  - 1678-4170 (Electronic)
IS  - 0066-782X (Linking)
VI  - 100
IP  - 5
DP  - 2013 May
TI  - Correlation to NT-ProBNP and remodeling after cardiac surgery.
PG  - 469-75
LID - S0066-782X2013005000018 [pii]
LID - 10.5935/abc.20130076 [doi]
AB  - BACKGROUND: Few data are available on diastolic function in patients with aortic 
      stenosis (AOS) with indication of surgical treatment. A potential correlation 
      between biomarkers and diastolic function has not been established. OBJECTIVE: 
      The aim of our study was to evaluate diastolic function in patients with AOS 
      waiting for aortic valve replacement (AVR) echocardiographically, and to verify 
      its correlation with serum brain natriuretic peptide (NT-proBNP). METHODS: 
      Thirty-one AOS patients (11 male), 21 to 81 years old (mean age, 61+/-15 years old) 
      were studied before and after AVR. Diastolic function was assessed with Doppler 
      methods: transvalvar mitral flow, tissue Doppler imaging (TDI) and pulmonary 
      venous Doppler (PVD), correlating with serum brain natriuretic peptide 
      (NT-proBNP) before and 6 months after AVR. RESULTS: Comparing pre to 
      post-operative period, we observed an increase of the left atrial ejection 
      fraction and isovolumetric relaxation time (IRT), and the decrease of the mitral 
      velocity to early diastolic velocity of the mitral annulus ratio (E/E'), the 
      difference between the pulmonary A wave duration and mitral A duration, left 
      atrial systolic volume, left atrial systolic volume index, left ventricular 
      diastolic diameter, left ventricular systolic diameter, end diastolic volume 
      (LVEDV), left ventricular mass index, left ventricular volume and mass index 
      ratio. The values of NT-proBNP were positively correlated to diastolic 
      dysfunction, both before and after surgery. CONCLUSION: AOS patients' ventricular 
      diastolic function improved after AVR. The biomarker NT-proBNP might be a useful 
      biomarker of diastolic function in these patients, before and after AVR. 
      NT-proBNP values show a positive correlation with echocardiographic variables 
      that determine diastolic dysfunction, and is a good marker for the 
      characterization of this dysfunction in AOS patients.
FAU - Boer, Berta Paula Napchan
AU  - Boer BP
AD  - Instituto do Coracao (InCor), Sao Paulo, SP - Brazil.
FAU - Vieira, Marcelo Luiz Campos
AU  - Vieira ML
FAU - Sampaio, Roney Orismar
AU  - Sampaio RO
FAU - Abensur, Henry
AU  - Abensur H
FAU - Oliveira, Alessandra Gomes de
AU  - Oliveira AG
FAU - Fernandes, Joao Ricardo
AU  - Fernandes JR
FAU - Grinberg, Max
AU  - Grinberg M
LA  - eng
LA  - por
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130412
PL  - Brazil
TA  - Arq Bras Cardiol
JT  - Arquivos brasileiros de cardiologia
JID - 0421031
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - *Aortic Valve Stenosis/blood/diagnostic imaging/physiopathology/surgery
MH  - Biomarkers/blood
MH  - Echocardiography, Doppler/methods
MH  - Female
MH  - *Heart Valve Prosthesis Implantation
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Postoperative Period
MH  - Preoperative Period
MH  - Stroke Volume/physiology
MH  - Treatment Outcome
MH  - *Ventricular Dysfunction, Left/blood/diagnostic imaging/physiopathology
MH  - Ventricular Remodeling/*physiology
MH  - Young Adult
EDAT- 2013/04/13 06:00
MHDA- 2014/01/18 06:00
CRDT- 2013/04/13 06:00
PHST- 2012/05/14 00:00 [received]
PHST- 2012/12/17 00:00 [accepted]
PHST- 2013/04/13 06:00 [entrez]
PHST- 2013/04/13 06:00 [pubmed]
PHST- 2014/01/18 06:00 [medline]
AID - S0066-782X2013005000018 [pii]
AID - 10.5935/abc.20130076 [doi]
PST - ppublish
SO  - Arq Bras Cardiol. 2013 May;100(5):469-75. doi: 10.5935/abc.20130076. Epub 2013 
      Apr 12.