PMID- 23579632
OWN - NLM
STAT- MEDLINE
DCOM- 20140314
LR  - 20211021
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 46
IP  - 4
DP  - 2013 Apr
TI  - Association of rs12255372 in the TCF7L2 gene with type 2 diabetes mellitus: a 
      meta-analysis.
PG  - 382-93
LID - S0100-879X2013005032677 [pii]
AB  - Our objective was to evaluate the association of rs12255372 in the TCF7L2 gene 
      with type 2 diabetes mellitus (T2DM) in the world population. We carried out a 
      survey of the literature about the effect of rs12255372 on genetic susceptibility 
      to T2DM by consulting PubMed, the Cochrane Library, and Embase from 2006 to 2012, 
      and then performed a meta-analysis of all the studies in order to evaluate the 
      association between rs12255372 and T2DM. A total of 33 articles including 42 
      studies (with 34,076 cases and 36,192 controls) were confirmed to be eligible and 
      were included in the final meta-analysis: 6 studies conducted on Europeans, 14 on 
      Caucasians, 17 on Asians, 2 on Africans, and 3 on Americans. Overall, the effect 
      size was as follows: for the variant allele T (OR = 1.387, 95%CI = 1.351-1.424), 
      for the TT genotype (OR = 1.933, 95%CI = 1.815-2.057), for the GT genotype (OR = 
      1.363, 95%CI = 1.315-1.413), for the dominant model (OR = 1.425, 95%CI = 
      1.344-1.510), and for the recessive model (OR = 1.659, 95%CI = 1.563-1.761). In 
      summary, by pooling all available qualified data from genetic studies on 
      rs12255372 and T2DM, we have confirmed that rs12255372 is significantly 
      associated with susceptibility to T2DM in the global population.
FAU - Wang, Jinjin
AU  - Wang J
AD  - Discipline of Public Health and Preventive Medicine, Center of Preventive 
      Medicine Research and Assessment, Henan University of Traditional Chinese 
      Medicine, Zhengzhou, China.
FAU - Zhang, Jianfeng
AU  - Zhang J
FAU - Li, Linlin
AU  - Li L
FAU - Wang, Yan
AU  - Wang Y
FAU - Wang, Qian
AU  - Wang Q
FAU - Zhai, Yujia
AU  - Zhai Y
FAU - You, Haifei
AU  - You H
FAU - Hu, Dongsheng
AU  - Hu D
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130412
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Alleles
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Transcription Factor 7-Like 2 Protein/*genetics
PMC - PMC3854403
EDAT- 2013/04/13 06:00
MHDA- 2014/03/15 06:00
PMCR- 2013/04/12
CRDT- 2013/04/13 06:00
PHST- 2012/10/16 00:00 [received]
PHST- 2013/01/25 00:00 [accepted]
PHST- 2013/04/13 06:00 [entrez]
PHST- 2013/04/13 06:00 [pubmed]
PHST- 2014/03/15 06:00 [medline]
PHST- 2013/04/12 00:00 [pmc-release]
AID - S0100-879X2013005032677 [pii]
AID - 10.1590/1414-431x20132677 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2013 Apr;46(4):382-93. doi: 10.1590/1414-431x20132677. Epub 
      2013 Apr 12.