PMID- 23580083
OWN - NLM
STAT- MEDLINE
DCOM- 20140706
LR  - 20211021
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 36
IP  - 9
DP  - 2013 Oct
TI  - Effects of short-term intensive glycemic control on insulin, glucagon, and 
      glucagon-like peptide-1 secretion in patients with Type 2 diabetes.
PG  - 734-8
LID - 10.3275/8934 [doi]
AB  - BACKGROUND: Short-term intensive insulin therapy (IIT) in patients with Type 2 
      diabetes mellitus (T2DM) has beneficial effects on insulin secretion. However, 
      IIT effect on glucagon and glucagon-like peptide-1 (GLP-1) secretion is unknown. 
      AIM: We evaluated short-term intensive glycemic control effects on insulin, 
      glucagon, and GLP-1 secretory dynamics in T2DM. MATERIALS AND METHODS: Twenty-six 
      patients with T2DM were hospitalized and treated with IIT for 10-14 days. A meal 
      tolerance test was performed before and after IIT and the differences in serum 
      immunoreactive insulin (IRI) and C-peptide immunoreactivity (CPR) as well as 
      plasma glucagon and active GLP-1 levels were evaluated. RESULTS: Glycoalbumin 
      levels decreased significantly from 23.0% before to 19.6% after IIT (p<0.001). 
      However, pre- and post-IIT, IRI and CPR levels were not significantly different; 
      post-IIT glucose levels were significantly decreased. The post-IIT glucagon 
      levels at 0 and 60 min were lower than pre-IIT levels. Moreover, post- IIT area 
      under the curve (AUC) of glucagon significantly reduced from 6755 +/- 996 pg/dl . 
      60 min to 5796 +/- 1074 pg/dl . 60 min (p<0.001). Furthermore, post-IIT GLP-1 
      levels and AUC were significantly higher than pre-IIT values. CONCLUSIONS: Our 
      results suggest that patients with T2DM who received shortterm IIT demonstrated 
      decreased postprandial glucagon levels and increased GLP-1 levels following a 
      meal tolerance test.
FAU - Shimodaira, M
AU  - Shimodaira M
AD  - Departments of Internal Medicine, Iida Municipal Hospital, 438 Yawata-machi, 
      Iida, Nagano, 395-8502, Japan. masanori19810813@yahoo.co.jp.
FAU - Muroya, Y
AU  - Muroya Y
FAU - Kumagai, N
AU  - Kumagai N
FAU - Tsuzawa, K
AU  - Tsuzawa K
FAU - Honda, K
AU  - Honda K
LA  - eng
PT  - Journal Article
DEP - 20130412
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Insulin)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Glucose/metabolism
MH  - C-Peptide/blood
MH  - Diabetes Mellitus, Type 2/*blood/drug therapy
MH  - Female
MH  - Glucagon/blood/*metabolism
MH  - Glucagon-Like Peptide 1/blood/*metabolism
MH  - Humans
MH  - Insulin/blood/metabolism/*therapeutic use
MH  - Insulin Secretion
MH  - Male
MH  - Middle Aged
EDAT- 2013/04/13 06:00
MHDA- 2014/07/07 06:00
CRDT- 2013/04/13 06:00
PHST- 2013/04/13 06:00 [entrez]
PHST- 2013/04/13 06:00 [pubmed]
PHST- 2014/07/07 06:00 [medline]
AID - 8934 [pii]
AID - 10.3275/8934 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2013 Oct;36(9):734-8. doi: 10.3275/8934. Epub 2013 Apr 12.