PMID- 23580785
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20211021
IS  - 1555-905X (Electronic)
IS  - 1555-9041 (Print)
IS  - 1555-9041 (Linking)
VI  - 8
IP  - 8
DP  - 2013 Aug
TI  - Asymptomatic pulmonary congestion and physical functioning in hemodialysis 
      patients.
PG  - 1343-8
LID - 10.2215/CJN.11111012 [doi]
AB  - BACKGROUND AND OBJECTIVES: Poor physical performance is common in patients with 
      kidney failure on dialysis (CKD-5D). Whether lung congestion, a predictable 
      consequence of cardiomyopathy and fluid overload, may contribute to the low 
      physical performance of CKD-5D patients has not been investigated in hemodialysis 
      patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This study investigated 
      the relationship between the physical functioning scale of the Kidney Disease 
      Quality of Life Short Form and a validated ultrasonographic measure of lung water 
      in a multicenter survey of 270 hemodialysis patients studied between 2009 and 
      2010. RESULTS: Moderate to severe lung congestion by lung ultrasonography was 
      observed in 156 (58%) patients; among these, 60 (38%) were asymptomatic (New York 
      Heart Association [NYHA] class I). On univariate analysis, physical functioning 
      was inversely associated with lung water in the whole group (r=-0.22; P<0.001) 
      and in the subgroup of asymptomatic patients (r=-0.40; P=0.002). Age (r=-0.45; 
      P<0.001) and past cardiovascular events (r=-0.22; P=0.002) were also inversely 
      associated with physical functioning, whereas albumin (r=0.23; P<0.001) was 
      directly associated with the same parameter. NYHA class correlated strongly with 
      physical functioning (r=-0.52; P<0.001). In a multiple regression analysis, both 
      NYHA class and lung water maintained an independent association with physical 
      functioning, whereas albumin and background cardiovascular events failed to 
      independently relate with the same outcome. CONCLUSIONS: Symptomatic and 
      asymptomatic lung congestion is associated with poor physical functioning in 
      hemodialysis patients. This association is independent of NYHA, suggesting that 
      this measurement and NYHA may have complementary value to explain the variability 
      in physical performance in hemodialysis patients.
FAU - Enia, Giuseppe
AU  - Enia G
AD  - Nephrology, Dialysis, Hypertension, and Renal Transplantation Unit, Azienda 
      Ospedaliera, Reggio Calabria, Italy. enia1951@gmail.com
FAU - Torino, Claudia
AU  - Torino C
FAU - Panuccio, Vincenzo
AU  - Panuccio V
FAU - Tripepi, Rocco
AU  - Tripepi R
FAU - Postorino, Maurizio
AU  - Postorino M
FAU - Aliotta, Roberta
AU  - Aliotta R
FAU - Bellantoni, Marianna
AU  - Bellantoni M
FAU - Tripepi, Giovanni
AU  - Tripepi G
FAU - Mallamaci, Francesca
AU  - Mallamaci F
FAU - Zoccali, Carmine
AU  - Zoccali C
CN  - Lung Comets Cohort Working Group
LA  - eng
PT  - Journal Article
DEP - 20130411
PL  - United States
TA  - Clin J Am Soc Nephrol
JT  - Clinical journal of the American Society of Nephrology : CJASN
JID - 101271570
SB  - IM
CIN - Clin J Am Soc Nephrol. 2013 Aug;8(8):1279-81. PMID: 23846460
MH  - Aged
MH  - Aged, 80 and over
MH  - Extravascular Lung Water/metabolism
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Lung/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - *Physical Conditioning, Human
MH  - Pulmonary Edema/*physiopathology
MH  - *Renal Dialysis
MH  - Ultrasonography
PMC - PMC3731913
FIR - Alati, Giovanni
IR  - Alati G
FIR - Boito, Rosalia
IR  - Boito R
FIR - Bonanno, Graziella
IR  - Bonanno G
FIR - Cassani, Simonetta
IR  - Cassani S
FIR - Chippari, Antonio
IR  - Chippari A
FIR - Cicchetti, Teresa
IR  - Cicchetti T
FIR - Clementi, Anna
IR  - Clementi A
FIR - Garozzo, Maurizio
IR  - Garozzo M
FIR - Logozzo, Domenico
IR  - Logozzo D
FIR - Luca, Rosita
IR  - Luca R
FIR - Mancuso, Domenico
IR  - Mancuso D
FIR - Mollica, Francesco
IR  - Mollica F
FIR - Natale, Giuseppe
IR  - Natale G
FIR - Sellaro, Arcangelo
IR  - Sellaro A
EDAT- 2013/04/13 06:00
MHDA- 2014/04/25 06:00
PMCR- 2014/07/31
CRDT- 2013/04/13 06:00
PHST- 2013/04/13 06:00 [entrez]
PHST- 2013/04/13 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
PHST- 2014/07/31 00:00 [pmc-release]
AID - CJN.11111012 [pii]
AID - 11111012 [pii]
AID - 10.2215/CJN.11111012 [doi]
PST - ppublish
SO  - Clin J Am Soc Nephrol. 2013 Aug;8(8):1343-8. doi: 10.2215/CJN.11111012. Epub 2013 
      Apr 11.