PMID- 23581178
OWN - NLM
STAT- MEDLINE
DCOM- 20150411
LR  - 20161125
IS  - 1000-6834 (Print)
IS  - 1000-6834 (Linking)
VI  - 28
IP  - 6
DP  - 2012 Nov
TI  - The acclimatization to extreme environments and its physiological mechanisms.
PG  - 494-503
AB  - Acclimatization is a process of biological adaptation when exposed to 
      environmental factors such as hypoxia, cold and heat for prolonged periods of 
      time, where non-genetical variations play a role in allowing subjects to tolerate 
      hypoxic, cold or hot environments. This review focuses on the characteristics and 
      mechanisms of acclimatization found through major research advances by our 
      institute. First, the mechanisms underlying the acclimatization to extreme 
      environments are complex. In our investigations, the physiological changes of 
      multiple systems including the nervous, circulatory, respiratory, and hemopoietic 
      system were demonstrated when the acclimatization to hypoxia was developed, and 
      the underlying significance of hypoxia-inducible factor-1 (HIF-1) was 
      investigated. Second, it is suggested that the development of acclimatization to 
      extreme environments is complicated. Hypoxia and cold coexist at high altitude. 
      Our investigations revealed the characteristics of negative cross-relationship in 
      the acclimatization to hypoxia and cold. And third, it is interesting for us to 
      understand that acclimatization to extreme environments is transferable among 
      individuals, and the characteristics of heat acclimatization-inducing factor 
      (HAlF) were presented. The above findings will provide a theoretical guidance for 
      protective operations and help to establish a solid foundation for future 
      research related to acclimatization.
FAU - Wang, Hai
AU  - Wang H
AD  - Institute of Health and Environmental Medicine, Academy of Military Medical 
      Sciences, Tianjin 300050, China. wh9588@yahoo.com.cn
FAU - Liu, Wei
AU  - Liu W
FAU - Yang, Dan-Feng
AU  - Yang DF
FAU - Zhao, Xiao-Ling
AU  - Zhao XL
FAU - Long, Chao-Liang
AU  - Long CL
FAU - Yin, Zhao-Yun
AU  - Yin ZY
FAU - Liu, Jia-Ying
AU  - Liu JY
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - Zhongguo Ying Yong Sheng Li Xue Za Zhi
JT  - Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = 
      Chinese journal of applied physiology
JID - 9426407
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
SB  - IM
MH  - Acclimatization/*physiology
MH  - Altitude
MH  - Cold Temperature
MH  - Environment
MH  - Hot Temperature
MH  - Humans
MH  - Hypoxia
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
EDAT- 2013/04/16 06:00
MHDA- 2015/04/12 06:00
CRDT- 2013/04/16 06:00
PHST- 2013/04/16 06:00 [entrez]
PHST- 2013/04/16 06:00 [pubmed]
PHST- 2015/04/12 06:00 [medline]
PST - ppublish
SO  - Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Nov;28(6):494-503.