PMID- 23582695
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20180816
IS  - 1873-6823 (Electronic)
IS  - 0741-8329 (Linking)
VI  - 47
IP  - 4
DP  - 2013 Jun
TI  - Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and its 
      implication in executive functions in adult offspring of alcohol-dependent 
      probands.
PG  - 271-4
LID - S0741-8329(13)00043-8 [pii]
LID - 10.1016/j.alcohol.2013.03.001 [doi]
AB  - Impairment of executive functions (EFs) mediated by the prefrontal lobe is 
      regarded as a cognitive endophenotype of alcohol dependence, being observed both 
      in probands and in healthy offspring. Given its impact on the anatomy of the 
      prefrontal cortex, the brain-derived neurotrophic factor (BDNF) Val66Met 
      polymorphism may well be involved in this specific endophenotype. Forty-six 
      healthy adult children of alcoholics (HACA) and 82 healthy controls (HC) took 
      part in the study. All the participants were assessed with the Diagnostic 
      Interview for Genetic Studies, and their family histories of alcohol and 
      substance use were assessed with the Family Informant Schedule and Criteria. The 
      Trail Making Test, Arithmetic Switching Task, Stroop Color-Word Test and 
      Wisconsin Card Sorting Test were administered to assess EFs. An overall executive 
      factor score was calculated using factorial analyses. Genotyping of the BDNF 
      Val66Met polymorphism was performed using the TaqMan(R) allelic discrimination 
      assay. HACA had significantly lower EFs performance than HC. Genetic analysis 
      showed that BDNF genotype distributions were in Hardy-Weinberg equilibrium in the 
      HACA and HC. Genotype and allele distributions did not differ significantly 
      between the two groups. Participants with the Met allele performed significantly 
      more poorly than participants with the Val allele, and a group by allele 
      interaction was observed, the BDNF Met allele being associated with a poorer 
      executive factor score in the HACA group. These results suggest that the BDNF 
      Val66Met polymorphism may contribute to alcohol dependence vulnerability via 
      lower EFs performance.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Benzerouk, Farid
AU  - Benzerouk F
AD  - Department of Psychiatry, Hopital Robert Debre, 51100 Reims, France. 
      fbenzerouk@chu-reims.fr
FAU - Gierski, Fabien
AU  - Gierski F
FAU - Gorwood, Philip
AU  - Gorwood P
FAU - Ramoz, Nicolas
AU  - Ramoz N
FAU - Stefaniak, Nicolas
AU  - Stefaniak N
FAU - Hubsch, Berengere
AU  - Hubsch B
FAU - Kaladjian, Arthur
AU  - Kaladjian A
FAU - Limosin, Frederic
AU  - Limosin F
LA  - eng
PT  - Journal Article
DEP - 20130410
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Adult Children/*psychology
MH  - Alcoholism/*genetics/*psychology
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - *Executive Function
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Pedigree
MH  - Phenotype
MH  - *Polymorphism, Genetic
MH  - Pregnancy
MH  - Surveys and Questionnaires
MH  - Young Adult
EDAT- 2013/04/16 06:00
MHDA- 2013/10/22 06:00
CRDT- 2013/04/16 06:00
PHST- 2012/10/29 00:00 [received]
PHST- 2013/01/25 00:00 [revised]
PHST- 2013/03/16 00:00 [accepted]
PHST- 2013/04/16 06:00 [entrez]
PHST- 2013/04/16 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
AID - S0741-8329(13)00043-8 [pii]
AID - 10.1016/j.alcohol.2013.03.001 [doi]
PST - ppublish
SO  - Alcohol. 2013 Jun;47(4):271-4. doi: 10.1016/j.alcohol.2013.03.001. Epub 2013 Apr 
      10.