PMID- 23582781
OWN - NLM
STAT- MEDLINE
DCOM- 20140108
LR  - 20130607
IS  - 1878-3279 (Electronic)
IS  - 0171-2985 (Linking)
VI  - 218
IP  - 8
DP  - 2013 Aug
TI  - Ageing impairs the T cell response to dendritic cells.
PG  - 1077-84
LID - S0171-2985(13)00039-9 [pii]
LID - 10.1016/j.imbio.2013.02.002 [doi]
AB  - Dendritic cells (DCs) are critical in priming adaptive T-cell responses, but the 
      effects of ageing on interactions between DCs and T cells are unclear. This study 
      investigated the influence of ageing on the maturation of and cytokine production 
      by human blood-enriched DCs, and the impact on T cell responses in an allogeneic 
      mixed leucocyte reaction (MLR). DCs from old subjects (65-75 y) produced 
      significantly less TNF-alpha and IFN-gamma than young subjects (20-30 y) in response to 
      lipopolysaccharide (LPS), but expression of maturation markers and co-stimulatory 
      molecules was preserved. In the MLR, DCs from older subjects induced 
      significantly restricted proliferation of young T cells, activation of CD8+ T 
      cells and expression of IL-12 and IFN-gamma in T cells compared with young DCs. T 
      cells from older subjects responded more weakly to DC stimulation compared with 
      young T cells, regardless of whether the DCs were derived from young or older 
      subjects. In conclusion, the capacity of DCs to induce T cell activation is 
      significantly impaired by ageing.
CI  - Copyright (c) 2013 Elsevier GmbH. All rights reserved.
FAU - You, Jialu
AU  - You J
AD  - Department of Food and Nutritional Sciences, The University of Reading, 
      Whiteknights PO Box 226, Reading RG6 6AP, UK.
FAU - Dong, Honglin
AU  - Dong H
FAU - Mann, Elizabeth R
AU  - Mann ER
FAU - Knight, Stella C
AU  - Knight SC
FAU - Yaqoob, Parveen
AU  - Yaqoob P
LA  - eng
GR  - BB/H00470X/1/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130301
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 187348-17-0 (Interleukin-12)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*immunology
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-12/biosynthesis
MH  - Leukocytes, Mononuclear/*immunology
MH  - Lipopolysaccharides
MH  - Lymphocyte Activation/*immunology
MH  - Lymphocyte Culture Test, Mixed
MH  - Tumor Necrosis Factor-alpha/biosynthesis
MH  - Young Adult
EDAT- 2013/04/16 06:00
MHDA- 2014/01/09 06:00
CRDT- 2013/04/16 06:00
PHST- 2013/01/08 00:00 [received]
PHST- 2013/02/19 00:00 [revised]
PHST- 2013/02/21 00:00 [accepted]
PHST- 2013/04/16 06:00 [entrez]
PHST- 2013/04/16 06:00 [pubmed]
PHST- 2014/01/09 06:00 [medline]
AID - S0171-2985(13)00039-9 [pii]
AID - 10.1016/j.imbio.2013.02.002 [doi]
PST - ppublish
SO  - Immunobiology. 2013 Aug;218(8):1077-84. doi: 10.1016/j.imbio.2013.02.002. Epub 
      2013 Mar 1.