PMID- 23583017
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20151119
IS  - 1879-1506 (Electronic)
IS  - 0003-9969 (Linking)
VI  - 58
IP  - 9
DP  - 2013 Sep
TI  - Experimental periodontitis promotes transient vascular inflammation and 
      endothelial dysfunction.
PG  - 1187-98
LID - S0003-9969(13)00103-9 [pii]
LID - 10.1016/j.archoralbio.2013.03.009 [doi]
AB  - OBJECTIVES: This study aimed to evaluate the systemic inflammatory response and 
      cardiovascular changes induced by experimental periodontitis in rats. DESIGN: 
      Experimental periodontitis was induced by placing a cotton ligature around the 
      cervix of both sides of mandibular first molars and maxillary second molars in 
      each male rat. Sham-operated rats had the ligature removed immediately after the 
      procedure. Seven, 14 or 28 days after procedure, the effects of acetylcholine, 
      sodium nitroprusside and phenylephrine were evaluated on blood pressure, aortic 
      rings and isolated and perfused mesenteric bed. The blood was obtained for plasma 
      Interleukin-6 (IL-6), C-reactive protein (CRP) and lipid evaluation. The 
      mesenteric vessels were obtained to evaluate superoxide production and nitric 
      oxide synthase 3 (NOS-3) expression. RESULTS: Ligature induced periodontitis 
      reduced endothelium-dependent vasodilatation, a hallmark of endothelial 
      dysfunction. This effect was associated with an increase in systemic inflammatory 
      markers (IL-6 and CRP), worsens on lipid profile, increased vascular superoxide 
      production and reduced NOS-3 expression. It is interesting to note that many of 
      these effects were transitory. CONCLUSION: Periodontitis induced a transient 
      systemic and vascular inflammation which leads to endothelial dysfunction, an 
      initial step for cardiovascular diseases. Moreover, the animal model of 
      periodontitis used here may represent a valuable tool for studying the 
      relationship between periodontitis and endothelial dysfunction.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Brito, Lorena C W
AU  - Brito LC
AD  - Department of Pharmaceutical Sciences, Universidade Estadual de Ponta Grossa, PR, 
      Brazil.
FAU - DalBo, Silvia
AU  - DalBo S
FAU - Striechen, Tatiane M
AU  - Striechen TM
FAU - Farias, Jessica M
AU  - Farias JM
FAU - Olchanheski, Luiz R Jr
AU  - Olchanheski LR Jr
FAU - Mendes, Reila T
AU  - Mendes RT
FAU - Vellosa, Jose C R
AU  - Vellosa JC
FAU - Favero, Giovani M
AU  - Favero GM
FAU - Sordi, Regina
AU  - Sordi R
FAU - Assreuy, Jamil
AU  - Assreuy J
FAU - Santos, Fabio A
AU  - Santos FA
FAU - Fernandes, Daniel
AU  - Fernandes D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130411
PL  - England
TA  - Arch Oral Biol
JT  - Archives of oral biology
JID - 0116711
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 11062-77-4 (Superoxides)
RN  - 169D1260KM (Nitroprusside)
RN  - 1WS297W6MV (Phenylephrine)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/pharmacology
MH  - Alveolar Bone Loss/physiopathology
MH  - Analysis of Variance
MH  - Animals
MH  - Biomarkers/analysis
MH  - C-Reactive Protein/analysis
MH  - Endothelium/*drug effects/metabolism
MH  - Inflammation/*complications/metabolism/physiopathology
MH  - Interleukin-6/blood
MH  - Male
MH  - Mesenteric Arteries/*drug effects/physiopathology
MH  - Microscopy, Fluorescence
MH  - Nitric Oxide Synthase/analysis
MH  - Nitroprusside/pharmacology
MH  - Periodontitis/*etiology/metabolism
MH  - Phenylephrine/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxides/analysis
MH  - Vasodilation/*drug effects
OTO - NOTNLM
OT  - Cholesterol
OT  - Endothelial dysfunction
OT  - Inflammation
OT  - Nitric oxide
OT  - Periodontitis
OT  - Superoxide
EDAT- 2013/04/16 06:00
MHDA- 2014/04/23 06:00
CRDT- 2013/04/16 06:00
PHST- 2012/10/30 00:00 [received]
PHST- 2013/02/05 00:00 [revised]
PHST- 2013/03/17 00:00 [accepted]
PHST- 2013/04/16 06:00 [entrez]
PHST- 2013/04/16 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
AID - S0003-9969(13)00103-9 [pii]
AID - 10.1016/j.archoralbio.2013.03.009 [doi]
PST - ppublish
SO  - Arch Oral Biol. 2013 Sep;58(9):1187-98. doi: 10.1016/j.archoralbio.2013.03.009. 
      Epub 2013 Apr 11.