PMID- 23583514
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20220408
IS  - 1464-3405 (Electronic)
IS  - 0960-894X (Linking)
VI  - 23
IP  - 10
DP  - 2013 May 15
TI  - Flaxseed (Linum usitatissimum L.) extract as well as (+)-secoisolariciresinol 
      diglucoside and its mammalian derivatives are potent inhibitors of alpha-amylase 
      activity.
PG  - 3007-12
LID - S0960-894X(13)00345-4 [pii]
LID - 10.1016/j.bmcl.2013.03.029 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is one of the common global diseases. Flaxseed is 
      by far the richest source of the dietary lignans (i.e., secoisolariciresinol 
      diglucoside) which have been shown to delay the development of T2DM in animal 
      models. Herein, we propose the first evidences for a mechanism of action 
      involving the inhibition of the pancreatic alpha-amylase (EC 3.2.1.1) by 
      flaxseed-derived lignans that could therefore constitute a promising 
      nutraceutical for the prevention and the treatment of T2DM.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Hano, Christophe
AU  - Hano C
AD  - Laboratoire de Biologie des Ligneux et des Grandes Cultures UPRES EA 1207, Equipe 
      Lignanes des Linacees, Antenne Scientifique Universitaire de Chartres, 21 rue de 
      Loigny la Bataille, F28000 Chartres, France. christophe.hano@univ-orleans.fr
FAU - Renouard, Sullivan
AU  - Renouard S
FAU - Molinie, Roland
AU  - Molinie R
FAU - Corbin, Cyrielle
AU  - Corbin C
FAU - Barakzoy, Esmatullah
AU  - Barakzoy E
FAU - Doussot, Joel
AU  - Doussot J
FAU - Lamblin, Frederic
AU  - Lamblin F
FAU - Laine, Eric
AU  - Laine E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130316
PL  - England
TA  - Bioorg Med Chem Lett
JT  - Bioorganic & medicinal chemistry letters
JID - 9107377
RN  - 0 (Butylene Glycols)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Glucosides)
RN  - 0 (Glycoside Hydrolase Inhibitors)
RN  - 0 (Lignans)
RN  - 0 (Plant Extracts)
RN  - EC 3.2.1.1 (Pancreatic alpha-Amylases)
RN  - EC 3.2.1.20 (alpha-Glucosidases)
RN  - M8QRJ7JEJH (secoisolariciresinol)
SB  - IM
MH  - Animals
MH  - Butylene Glycols/chemistry/isolation & purification/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Enzyme Inhibitors/chemistry/isolation & purification/*pharmacology
MH  - Flax/*chemistry
MH  - Glucosides/chemistry/isolation & purification/*pharmacology
MH  - Glycoside Hydrolase Inhibitors
MH  - Intestines/enzymology
MH  - Lignans/chemistry/isolation & purification/*pharmacology
MH  - Molecular Structure
MH  - Pancreatic alpha-Amylases/*antagonists & inhibitors/metabolism
MH  - Plant Extracts/*chemistry
MH  - Rats
MH  - Structure-Activity Relationship
MH  - Swine
MH  - alpha-Glucosidases/metabolism
EDAT- 2013/04/16 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/04/16 06:00
PHST- 2012/12/26 00:00 [received]
PHST- 2013/03/05 00:00 [revised]
PHST- 2013/03/07 00:00 [accepted]
PHST- 2013/04/16 06:00 [entrez]
PHST- 2013/04/16 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - S0960-894X(13)00345-4 [pii]
AID - 10.1016/j.bmcl.2013.03.029 [doi]
PST - ppublish
SO  - Bioorg Med Chem Lett. 2013 May 15;23(10):3007-12. doi: 
      10.1016/j.bmcl.2013.03.029. Epub 2013 Mar 16.