PMID- 23583595
OWN - NLM
STAT- MEDLINE
DCOM- 20140106
LR  - 20211021
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 544
DP  - 2013 Jun 7
TI  - Reduced cocaine-seeking behavior in heterozygous BDNF knockout rats.
PG  - 94-9
LID - S0304-3940(13)00293-0 [pii]
LID - 10.1016/j.neulet.2013.03.050 [doi]
AB  - Cocaine generates drug-seeking behavior by creating long-lasting changes in the 
      reward pathway. The role of the growth factor, brain-derived neurotrophic factor 
      (BDNF) in facilitating these changes was investigated in the present report with 
      a genetic rat model. Using conditioned place preference, the current study 
      investigated the hypothesis that a partial knockout of the BDNF gene in rats 
      (BDNF(+/-)) would attenuate the rewarding effects of cocaine. Wildtype rats 
      exposed to cocaine exhibited normal cocaine-seeking responses one day after 
      conditioning and cocaine-seeking behavior was reinstated with drug priming 
      following drug abstinence. In contrast, BDNF(+/-) rats did not show 
      cocaine-seeking behavior one day after conditioning, nor did they respond to drug 
      priming. A median split of rats based on BDNF levels in sera collected prior to 
      behavioral procedures revealed that wildtype rats with high BDNF levels showed 
      stronger conditioned place preference and reinstatement to cocaine. Together, the 
      results support the hypothesis that a partial knockout of the BDNF gene 
      attenuates the rewarding properties of cocaine. Additionally, individual 
      differences in BDNF levels may predict future cocaine-seeking behavior. An 
      underlying mechanism of these effects may be a reduction of the amount of 
      synaptic changes made in the reward pathway.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - St Laurent, Robyn
AU  - St Laurent R
AD  - Department of Psychology, Colby College, Waterville, ME 04901, USA.
FAU - Helm, Samuel R
AU  - Helm SR
FAU - Glenn, Melissa J
AU  - Glenn MJ
LA  - eng
GR  - P20 GM103423/GM/NIGMS NIH HHS/United States
GR  - P20 RR016463/RR/NCRR NIH HHS/United States
GR  - 5P20RR016463-12/RR/NCRR NIH HHS/United States
GR  - 8P20GM103423-12/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130409
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*blood/genetics
MH  - Cocaine/*pharmacology
MH  - Cocaine-Related Disorders/*blood
MH  - Drug-Seeking Behavior/*drug effects/*physiology
MH  - Female
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Repetition Priming/drug effects/*physiology
MH  - *Reward
PMC - PMC3773519
MID - NIHMS474489
EDAT- 2013/04/16 06:00
MHDA- 2014/01/07 06:00
PMCR- 2014/06/07
CRDT- 2013/04/16 06:00
PHST- 2013/01/07 00:00 [received]
PHST- 2013/03/07 00:00 [revised]
PHST- 2013/03/21 00:00 [accepted]
PHST- 2013/04/16 06:00 [entrez]
PHST- 2013/04/16 06:00 [pubmed]
PHST- 2014/01/07 06:00 [medline]
PHST- 2014/06/07 00:00 [pmc-release]
AID - S0304-3940(13)00293-0 [pii]
AID - 10.1016/j.neulet.2013.03.050 [doi]
PST - ppublish
SO  - Neurosci Lett. 2013 Jun 7;544:94-9. doi: 10.1016/j.neulet.2013.03.050. Epub 2013 
      Apr 9.