PMID- 23584115
OWN - NLM
STAT- MEDLINE
DCOM- 20130701
LR  - 20211021
IS  - 2168-3492 (Print)
IS  - 2169-4796 (Electronic)
IS  - 2168-3492 (Linking)
VI  - 34
IP  - 4
DP  - 2012
TI  - Stress, epigenetics, and alcoholism.
PG  - 495-505
AB  - Acute and chronic stressors have been associated with alterations in mood and 
      increased anxiety that may eventually result in the development of stress-related 
      psychiatric disorders. Stress and associated disorders, including anxiety, are 
      key factors in the development of alcoholism because alcohol consumption can 
      temporarily reduce the drinker's dysphoria. One molecule that may help mediate 
      the relationship between stress and alcohol consumption is brain-derived 
      neurotrophic factor (BDNF), a protein that regulates the structure and function 
      of the sites where two nerve cells interact and exchange nerve signals (i.e., 
      synapses) and which is involved in numerous physiological processes. Aberrant 
      regulation of BDNF signaling and alterations in synapse activity (i.e., synaptic 
      plasticity) have been associated with the pathophysiology of stress-related 
      disorders and alcoholism. Mechanisms that contribute to the regulation of genetic 
      information without modification of the DNA sequence (i.e., epigenetic 
      mechanisms) may play a role in the complex control of BDNF signaling and synaptic 
      plasticity-for example, by modifying the structure of the DNA-protein complexes 
      (i.e., chromatin) that make up the chromosomes and thereby modulating the 
      expression of certain genes. Studies regarding the epigenetic control of BDNF 
      signaling and synaptic plasticity provide a promising direction to understand the 
      mechanisms mediating the interaction between stress and alcoholism.
FAU - Moonat, Sachin
AU  - Moonat S
AD  - University of Illinois, Chicago, IL, USA.
FAU - Pandey, Subhash C
AU  - Pandey SC
LA  - eng
GR  - R29 AA010005/AA/NIAAA NIH HHS/United States
GR  - U01 AA019971/AA/NIAAA NIH HHS/United States
GR  - AA-019971/AA/NIAAA NIH HHS/United States
GR  - AA-016690/AA/NIAAA NIH HHS/United States
GR  - R01 AA010005/AA/NIAAA NIH HHS/United States
GR  - R01 AA016690/AA/NIAAA NIH HHS/United States
GR  - R01 AA013341/AA/NIAAA NIH HHS/United States
GR  - AA-013341/AA/NIAAA NIH HHS/United States
GR  - AA-010005/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Alcohol Res
JT  - Alcohol research : current reviews
JID - 101594475
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Alcoholism/*genetics/physiopathology
MH  - Brain-Derived Neurotrophic Factor/genetics/physiology
MH  - *Epigenesis, Genetic
MH  - Humans
MH  - Signal Transduction/genetics/physiology
MH  - Stress, Psychological/*genetics/physiopathology
PMC - PMC3860391
EDAT- 2012/01/01 00:00
MHDA- 2013/07/03 06:00
PMCR- 2012/01/01
CRDT- 2013/04/16 06:00
PHST- 2013/04/16 06:00 [entrez]
PHST- 2012/01/01 00:00 [pubmed]
PHST- 2013/07/03 06:00 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - arcr-34-4-495 [pii]
PST - ppublish
SO  - Alcohol Res. 2012;34(4):495-505.