PMID- 23584697
OWN - NLM
STAT- MEDLINE
DCOM- 20140205
LR  - 20211021
IS  - 1539-2864 (Electronic)
IS  - 0275-004X (Print)
IS  - 0275-004X (Linking)
VI  - 33
IP  - 8
DP  - 2013 Sep
TI  - Safety and efficacy of oral fluorescein angiography in detecting macular edema in 
      comparison with spectral-domain optical coherence tomography.
PG  - 1574-83
LID - 10.1097/IAE.0b013e318285cd84 [doi]
AB  - PURPOSE: To evaluate the safety of oral fluorescein angiography (FA) and to 
      compare its efficacy in detection of macular edema (ME) with spectral-domain 
      optical coherence tomography (SD-OCT). METHODS: Results of imaging studies for 
      1,928 eyes of 1,019 patients who had simultaneously undergone both oral FA and 
      SD-OCT by a confocal laser ophthalmoscope were reviewed. Sensitivity in detecting 
      ME, discrepancy rate, and "kappa" agreement were determined for both the 
      techniques and with eyes stratified by disease diagnosis. RESULTS: No allergic 
      reactions occurred after oral FA. Mild gastric discomfort was noted in <1% of the 
      patients; 1,840 eyes (95.4%) showed concordance between the two techniques, and 
      kappa agreement was 90.3%. For ME, oral FA showed an overall sensitivity of 0.97 
      and SD-OCT of 0.91. Equivalent sensitivity was found in cases of wet age-related 
      macular degeneration (0.99). Oral FA was more sensitive than SD-OCT in cases of 
      retinovascular diseases. The SD-OCT showed higher sensitivity in cases of macular 
      holes. Detection of ME by SD-OCT was significantly higher in cases of intense 
      leakage on oral FA (P < 0.001). CONCLUSION: Oral FA proved to be a safe and an 
      adequate technique to evaluate ME. It is more sensitive than SD-OCT in detection 
      of ME in cases of retinovascular diseases but can fail to detect ME in cases of 
      macular holes. A noninvasive examination with simultaneous oral FA and SD-OCT may 
      be considered to obtain a comprehensive evaluation of the presence of ME from 
      different pathologies.
FAU - Barteselli, Giulio
AU  - Barteselli G
AD  - Department of Ophthalmology, Jacobs Retina Center at Shiley Eye Center, 
      University of California San Diego, La Jolla, CA, USA.
FAU - Chhablani, Jay
AU  - Chhablani J
FAU - Lee, Su Na
AU  - Lee SN
FAU - Wang, Haiyan
AU  - Wang H
FAU - El Emam, Sharif
AU  - El Emam S
FAU - Kozak, Igor
AU  - Kozak I
FAU - Cheng, Lingyun
AU  - Cheng L
FAU - Bartsch, Dirk-Uwe
AU  - Bartsch DU
FAU - Azen, Stanley
AU  - Azen S
FAU - Freeman, William R
AU  - Freeman WR
LA  - eng
GR  - R01EY020617/EY/NEI NIH HHS/United States
GR  - R01 EY018589/EY/NEI NIH HHS/United States
GR  - R01EY018589/EY/NEI NIH HHS/United States
GR  - R01 EY016323/EY/NEI NIH HHS/United States
GR  - R01EY016323/EY/NEI NIH HHS/United States
GR  - R01EY007366/EY/NEI NIH HHS/United States
GR  - R01 EY007366/EY/NEI NIH HHS/United States
GR  - R01 EY020617/EY/NEI NIH HHS/United States
GR  - P30 EY022589/EY/NEI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
RN  - 0 (Fluorescent Dyes)
RN  - TPY09G7XIR (Fluorescein)
SB  - IM
MH  - Administration, Oral
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Female
MH  - *Fluorescein/administration & dosage/adverse effects
MH  - Fluorescein Angiography/*methods
MH  - *Fluorescent Dyes/administration & dosage/adverse effects
MH  - Humans
MH  - Macular Edema/*diagnosis
MH  - Male
MH  - Middle Aged
MH  - Observer Variation
MH  - Ophthalmoscopy
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Tomography, Optical Coherence/*methods
MH  - Treatment Outcome
MH  - Visual Acuity/physiology
MH  - Young Adult
PMC - PMC3804067
MID - NIHMS508676
COIS- The authors have no proprietary, financial, or conflicts of interest to disclose.
EDAT- 2013/04/16 06:00
MHDA- 2014/02/06 06:00
PMCR- 2014/09/01
CRDT- 2013/04/16 06:00
PHST- 2013/04/16 06:00 [entrez]
PHST- 2013/04/16 06:00 [pubmed]
PHST- 2014/02/06 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - 10.1097/IAE.0b013e318285cd84 [doi]
PST - ppublish
SO  - Retina. 2013 Sep;33(8):1574-83. doi: 10.1097/IAE.0b013e318285cd84.