PMID- 23585223
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20140320
IS  - 1439-1902 (Electronic)
IS  - 0171-6425 (Linking)
VI  - 62
IP  - 2
DP  - 2014 Mar
TI  - Analysis of predictive factors for postoperative survival for non small cell lung 
      carcinoma patients with unexpected mediastinal lymph nodes metastasis.
PG  - 126-32
LID - 10.1055/s-0033-1338132 [doi]
AB  - OBJECTIVES: To discuss the predictive factors of postoperative survival for non 
      small cell lung carcinoma (NSCLC) patients with clinical N0 stage but 
      postoperative pathological N2 stage (cN0-pN2). METHODS: From January 1, 2005, to 
      December 31, 2009, the clinical data of NSCLC patients with cN0-pN2 after radical 
      surgery were retrospectively collected, and their survival information was 
      collected through follow-up. The expiration date for follow-up was December 31, 
      2011. The predictive factors of postoperative survival for NSCLC patients with 
      unexpected mediastinal lymph node metastasis were analyzed using Cox proportional 
      hazards regression. RESULTS: A total of 263 patients were enrolled. The follow-up 
      rate was 91.63%. The overall 1-, 3-, and 5-year survival rates were 94.6, 55.2, 
      and 26.3%, respectively. Video-assisted thoracotomy surgery (VATS; odds ratio 
      [OR] 0.659; 95% confidence interval [CI] 0.469 to 0.927; p = 0.017), multiple 
      stations of metastatic mediastinal lymph nodes (OR 1.605; 95% CI 1.180 to 2.183; 
      p = 0.003), and no adjuvant chemotherapy (OR 1.576; 95% CI 1.105 to 2.246; 
      p = 0.012) were independent predictive factors for unexpected N2 patients. The 
      median survival after VATS was superior to that after thoracotomy for patients 
      with a single station of metastatic mediastinal lymph node (48.45 m vs 37.34 m, 
      p = 0.018). The median survival without any adjuvant chemotherapy was inferior to 
      that after adjuvant chemotherapy for patients with multiple stations of 
      metastatic mediastinal lymph nodes (20.32 m vs 31.55 m, p = 0.001). CONCLUSION: 
      The postoperative survival for NSCLC patients with cN0-pN2 was related to 
      operational method, adjuvant chemotherapy, and the number of metastatic 
      mediastinal lymph node stations. Patients with a single station of metastatic 
      mediastinal lymph node are likely to benefit from VATS, whereas patients with 
      multiple stations of metastatic mediastinal lymph nodes are likely to benefit 
      from adjuvant chemotherapy.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Wang, Shaohua
AU  - Wang S
AD  - Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 
      Shanghai, China.
FAU - Zhou, Wenyong
AU  - Zhou W
AD  - Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 
      Shanghai, China.
FAU - Zhang, Hui
AU  - Zhang H
AD  - Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 
      Shanghai, China.
FAU - Zhao, Mingchuan
AU  - Zhao M
AD  - Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 
      Shanghai, China.
FAU - Chen, Xiaofeng
AU  - Chen X
AD  - Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20130412
PL  - Germany
TA  - Thorac Cardiovasc Surg
JT  - The Thoracic and cardiovascular surgeon
JID - 7903387
SB  - IM
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/*mortality/secondary/surgery
MH  - China/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lung Neoplasms/*mortality/pathology/surgery
MH  - Lymph Node Excision
MH  - Lymphatic Metastasis
MH  - Male
MH  - Mediastinum
MH  - Neoplasm Staging
MH  - Pneumonectomy/*methods
MH  - Postoperative Period
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate/trends
MH  - Treatment Outcome
EDAT- 2013/04/16 06:00
MHDA- 2014/12/15 06:00
CRDT- 2013/04/16 06:00
PHST- 2013/04/16 06:00 [entrez]
PHST- 2013/04/16 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1055/s-0033-1338132 [doi]
PST - ppublish
SO  - Thorac Cardiovasc Surg. 2014 Mar;62(2):126-32. doi: 10.1055/s-0033-1338132. Epub 
      2013 Apr 12.