PMID- 23586783
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1502-7686 (Electronic)
IS  - 0036-5513 (Linking)
VI  - 73
IP  - 4
DP  - 2013
TI  - Impact of atrial fibrillation on inflammatory and fibrinolytic variables in the 
      elderly.
PG  - 326-33
LID - 10.3109/00365513.2013.780093 [doi]
AB  - PURPOSE: Atrial fibrillation (AF) is associated with inflammation and a 
      prothrombotic state; however, it is still unclear whether this is independent of 
      ageing and comorbidity. The objective of this study was to investigate the impact 
      of AF on circulating levels of inflammatory and fibrinolytic markers in a 
      75-year-old general population. METHODS: All 75-year-old citizens in Asker and 
      Baerum counties in Norway were invited to participate in a prevalence study of 
      AF. Blood samples were collected from 63 subjects with AF and a gender-matched 
      control group of 126 subjects in sinus rhythm. C-reactive protein (CRP), tumour 
      necrosis factor alpha (TNFalpha), interleukin-6 (IL-6), monocyte chemoattractant 
      protein-1 (MCP-1), P-selectin, CD40 ligand, tissue plasminogen activator antigen 
      (tPA ag), plasminogen activator inhibitor-1 (PAI-1), matrix metalloproteinase-9 
      (MMP-9) and tissue inhibitor of metalloproteinase inhibitor 1 (TIMP-1) activity 
      were analyzed using commercially available assays. RESULTS: Subjects with AF had 
      higher levels of IL-6 (median 3.07 pg/mL (interquartile range 2.11, 4.36) vs. 
      2.26 (1.70, 3.26); p = 0.002) and PAI-1 activity (12.9 U/mL (6.6, 17.1) vs. 9.0 
      (4.6, 14.0); p = 0.005). No difference was found for the other markers. The 
      presence of AF was still significantly associated with higher levels of IL-6 and 
      PAI-1 activity after adjusting for confounders (p = 0.028 and p = 0.007, 
      respectively). CONCLUSION: AF was independently associated with higher levels of 
      IL-6 and PAI-1 activity. Thus, there is evidence of a proinflammatory state and 
      reduced fibrinolysis also in this stable, out-of-hospital group of 75-year-old AF 
      patients.
FAU - Berge, Trygve
AU  - Berge T
AD  - a Department of Medical Research, Vestre Viken Hospital Trust, Baerum Hospital , 
      Rud.
FAU - Ulimoen, Sara R
AU  - Ulimoen SR
AD  - a Department of Medical Research, Vestre Viken Hospital Trust, Baerum Hospital , 
      Rud.
FAU - Enger, Steve
AU  - Enger S
AD  - a Department of Medical Research, Vestre Viken Hospital Trust, Baerum Hospital , 
      Rud.
FAU - Arnesen, Harald
AU  - Arnesen H
AD  - b Center for Clinical Heart Research, Department of Cardiology, Oslo University 
      Hospital Ulleval , Oslo.
AD  - c Faculty of Medicine, University of Oslo , Oslo, Norway.
FAU - Seljeflot, Ingebjorg
AU  - Seljeflot I
AD  - b Center for Clinical Heart Research, Department of Cardiology, Oslo University 
      Hospital Ulleval , Oslo.
AD  - c Faculty of Medicine, University of Oslo , Oslo, Norway.
FAU - Tveit, Arnljot
AU  - Tveit A
AD  - a Department of Medical Research, Vestre Viken Hospital Trust, Baerum Hospital , 
      Rud.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130416
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 0 (Biomarkers)
RN  - 0 (IL6 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (SERPINE1 protein, human)
RN  - 0 (TIMP1 protein, human)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/*blood
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Female
MH  - *Fibrinolysis
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Matrix Metalloproteinase 9/blood
MH  - Norway
MH  - Plasminogen Activator Inhibitor 1/blood
MH  - Tissue Inhibitor of Metalloproteinase-1/blood
OTO - NOTNLM
OT  - Atrial fibrillation
OT  - C-reactive protein
OT  - cardiology
OT  - inflammation mediators
OT  - interleukin-6
OT  - plasminogen activator inhibitor 1
EDAT- 2013/04/17 06:00
MHDA- 2016/12/15 06:00
CRDT- 2013/04/17 06:00
PHST- 2013/04/17 06:00 [entrez]
PHST- 2013/04/17 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.3109/00365513.2013.780093 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 2013;73(4):326-33. doi: 10.3109/00365513.2013.780093. 
      Epub 2013 Apr 16.