PMID- 23587681
OWN - NLM
STAT- MEDLINE
DCOM- 20140106
LR  - 20130603
IS  - 1095-9947 (Electronic)
IS  - 1050-4648 (Linking)
VI  - 35
IP  - 1
DP  - 2013 Jul
TI  - In vitro immunopathogenesis of Edwardsiella tarda in catla Catla catla 
      (Hamilton).
PG  - 175-9
LID - S1050-4648(13)00491-9 [pii]
LID - 10.1016/j.fsi.2013.04.002 [doi]
AB  - Immunopathogenesis of Edwardsiella tarda in Catla (Catla catla) was evaluated by 
      in vitro interaction of catla head kidney (HK) phagocytes with the bacterium. 
      Interactions of E. tarda with catla HK phagocytes were studied by light 
      microscopy as well as by phagocytosis, intracellular replication, superoxide 
      anion and nitric oxide production assays. Both opsonised and non-opsonized 
      bacteria could adhere to, survive and replicate within phagocytes. Furthermore, 
      there was no significant alteration in superoxide anion production by phagocytes 
      when infected with E. tarda, indicating that they were able to avoid and/or 
      resist reactive oxygen species mediated killing by the phagocytes. Enhancement of 
      nitric oxide production indicated its possible involvement as inflammation 
      mediator to facilitate pathogenesis. The results suggest the fact that E. tarda 
      strain has the ability to resist phagocyte mediated killing, thereby 
      proliferating within the host and causing infection.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Nakhro, Khriezhato
AU  - Nakhro K
AD  - Department of Fish Health and Environment, College of Fisheries, Central 
      Agricultural University, Lembucherra, Agartala, Tripura, India.
FAU - Devi, Thongam Bidya
AU  - Devi TB
FAU - Kamilya, Dibyendu
AU  - Kamilya D
LA  - eng
PT  - Journal Article
DEP - 20130412
PL  - England
TA  - Fish Shellfish Immunol
JT  - Fish & shellfish immunology
JID - 9505220
RN  - 11062-77-4 (Superoxides)
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Animals
MH  - *Cyprinidae
MH  - Edwardsiella tarda/*pathogenicity/physiology
MH  - Enterobacteriaceae Infections/immunology/*veterinary
MH  - Fish Diseases/*immunology
MH  - Head Kidney/*immunology/microbiology
MH  - Nitric Oxide/metabolism
MH  - Phagocytes/*immunology/microbiology
MH  - Phagocytosis
MH  - Superoxides/metabolism
MH  - Virulence
EDAT- 2013/04/17 06:00
MHDA- 2014/01/07 06:00
CRDT- 2013/04/17 06:00
PHST- 2013/02/11 00:00 [received]
PHST- 2013/03/13 00:00 [revised]
PHST- 2013/04/04 00:00 [accepted]
PHST- 2013/04/17 06:00 [entrez]
PHST- 2013/04/17 06:00 [pubmed]
PHST- 2014/01/07 06:00 [medline]
AID - S1050-4648(13)00491-9 [pii]
AID - 10.1016/j.fsi.2013.04.002 [doi]
PST - ppublish
SO  - Fish Shellfish Immunol. 2013 Jul;35(1):175-9. doi: 10.1016/j.fsi.2013.04.002. 
      Epub 2013 Apr 12.