PMID- 2358774
OWN - NLM
STAT- MEDLINE
DCOM- 19900801
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 172
IP  - 1
DP  - 1990 Jul 1
TI  - Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by 
      human T lymphotropic virus type 1 tax: a potential mechanism for the increased 
      production of TGF-beta 1 in adult T cell leukemia.
PG  - 121-9
AB  - We examined the effect of the human T lymphotropic virus type 1 (HTLV-I) Tax gene 
      product on the human transforming growth factor beta 1 (TGF-beta 1) promoter. 
      Transfection of deleted constructs of the TGF-beta 1 promoter revealed regions 
      homologous with AP-1 binding sites that were required for Tax-induced 
      transactivation of the TGF-beta 1 promoter. In addition, we examined the 
      expression and secretion of TGF-beta in fresh leukemic cells isolated from 
      patients with adult T cell leukemia (ATL) and in HTLV-1-infected T cell lines. We 
      report that fresh leukemic cells from ATL patients constitutively produce high 
      levels of TGF-beta 1 mRNA and secrete TGF-beta 1 but not TGF-beta 2 into the 
      culture medium. In addition, long-term ATL cell lines expressed significant 
      amounts of TGF-beta 1 mRNA as well as detectable levels of TGF-beta 1 protein. 
      These results suggest a role for Tax in the upregulation of TGF-beta 1 in 
      HTLV-I-infected cells.
FAU - Kim, S J
AU  - Kim SJ
AD  - Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 
      20892.
FAU - Kehrl, J H
AU  - Kehrl JH
FAU - Burton, J
AU  - Burton J
FAU - Tendler, C L
AU  - Tendler CL
FAU - Jeang, K T
AU  - Jeang KT
FAU - Danielpour, D
AU  - Danielpour D
FAU - Thevenin, C
AU  - Thevenin C
FAU - Kim, K Y
AU  - Kim KY
FAU - Sporn, M B
AU  - Sporn MB
FAU - Roberts, A B
AU  - Roberts AB
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (RNA, Messenger)
RN  - 0 (Trans-Activators)
RN  - 76057-06-2 (Transforming Growth Factors)
SB  - IM
MH  - Cell Line
MH  - Chromosome Deletion
MH  - *Gene Expression
MH  - Human T-lymphotropic virus 1/*genetics
MH  - Humans
MH  - Leukemia, T-Cell/genetics/*metabolism/microbiology
MH  - Mutation
MH  - Plasmids
MH  - Promoter Regions, Genetic
MH  - RNA, Messenger/genetics
MH  - Restriction Mapping
MH  - Trans-Activators/*metabolism
MH  - Transfection
MH  - Transforming Growth Factors/biosynthesis/*genetics
PMC - PMC2188182
EDAT- 1990/07/01 00:00
MHDA- 1990/07/01 00:01
PMCR- 1991/01/01
CRDT- 1990/07/01 00:00
PHST- 1990/07/01 00:00 [pubmed]
PHST- 1990/07/01 00:01 [medline]
PHST- 1990/07/01 00:00 [entrez]
PHST- 1991/01/01 00:00 [pmc-release]
AID - 90293671 [pii]
AID - 10.1084/jem.172.1.121 [doi]
PST - ppublish
SO  - J Exp Med. 1990 Jul 1;172(1):121-9. doi: 10.1084/jem.172.1.121.