PMID- 23587914
OWN - NLM
STAT- MEDLINE
DCOM- 20130711
LR  - 20130517
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 523
IP  - 1
DP  - 2013 Jul 1
TI  - Interleukin-18 gene polymorphisms and rheumatoid arthritis: a meta-analysis.
PG  - 27-32
LID - S0378-1119(13)00427-7 [pii]
LID - 10.1016/j.gene.2013.03.132 [doi]
AB  - Interleukin-18 (IL-18) is a member of the IL-1 superfamily that enhances both 
      innate and acquired immune responses. IL-18 is highly expressed in sera, synovial 
      fluids and synovial tissues of patients with RA, and these IL-18 levels are 
      correlated with RA disease activity, indicating an important role of IL-18 in the 
      pathogenesis of RA. Several studies have examined the association of IL-18 gene 
      polymorphisms with RA, but these studies have shown inconclusive and 
      controversial results. To verify the association between IL-18 gene polymorphism 
      and susceptibility to RA, we conducted a meta-analysis of all relevant reports 
      cited in MEDLINE/PubMed before October 2012. A meta-analysis on the association 
      between the IL-18 rs1946518 SNP and RA was performed for 2944 patients with RA 
      and 2377 controls from 7 published studies and a meta-analysis on the association 
      between the IL-18 rs187238 SNP and RA was performed for 1319 patients with RA and 
      1211 controls from 5 published studies. In addition, 2 studies involving 1873 RA 
      patients and 1092 controls were considered in the meta-analysis of the 
      association between the IL-18 rs360722 SNP and RA. No significant association was 
      found between two IL-18 SNPs (rs1946518 and rs187238) and RA susceptibility in 
      all subjects. In subgroup analysis stratified by ethnicity, there was still no 
      significant association between these two IL-18 SNPs and RA susceptibility. 
      However, the frequency of the T allele at rs360722 was found to be significantly 
      lower in patients with RA compared with controls, although this finding was based 
      on only 2 studies. The results of our meta-analysis suggest that IL-18 rs360722 
      SNP is only associated with RA susceptibility. However, due to only two studies 
      included in our meta-analysis, large-scale well designed studies should be 
      considered in future studies to confirm the exact role of IL-18 rs360722 SNP in 
      RA susceptibility.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Ji, Jong Dae
AU  - Ji JD
AD  - Rheumatology, College of Medicine, Korea University, 126-1, Anam-Dong 5-Ga, 
      Sungbuk-Ku, Seoul 136-705, South Korea. jjdjmesy@korea.ac.kr
FAU - Lee, Won Jin
AU  - Lee WJ
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20130413
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Alleles
MH  - Arthritis, Rheumatoid/ethnology/*genetics
MH  - Databases, Factual
MH  - Gene Frequency
MH  - Genetic Association Studies/methods
MH  - Genetic Predisposition to Disease
MH  - Genetics, Population/methods
MH  - *Genome, Human
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Publication Bias
EDAT- 2013/04/17 06:00
MHDA- 2013/07/13 06:00
CRDT- 2013/04/17 06:00
PHST- 2012/11/12 00:00 [received]
PHST- 2013/03/17 00:00 [revised]
PHST- 2013/03/27 00:00 [accepted]
PHST- 2013/04/17 06:00 [entrez]
PHST- 2013/04/17 06:00 [pubmed]
PHST- 2013/07/13 06:00 [medline]
AID - S0378-1119(13)00427-7 [pii]
AID - 10.1016/j.gene.2013.03.132 [doi]
PST - ppublish
SO  - Gene. 2013 Jul 1;523(1):27-32. doi: 10.1016/j.gene.2013.03.132. Epub 2013 Apr 13.