PMID- 23588515
OWN - NLM
STAT- MEDLINE
DCOM- 20140310
LR  - 20220330
IS  - 1809-4570 (Electronic)
IS  - 0482-5004 (Linking)
VI  - 53
IP  - 1
DP  - 2013 Feb
TI  - HLA-DRB1 allele association with rheumatoid arthritis susceptibility and severity 
      in Syria.
PG  - 47-56
AB  - INTRODUCTION: Rheumatoid arthritis (RA) is a complex multifactorial chronic 
      disease. The importance of human leukocyte antigen as a major genetic risk factor 
      for RA was studied worldwide. Although it is widely distributed in different 
      Syrian areas, studies of human leukocyte antigen (HLA) alleles' role are absent. 
      OBJECTIVE: The aim of our study was to determine the association of HLA-DRB1 
      alleles with the susceptibility and severity of RA in Syria. PATIENTS AND 
      METHODS: Eighty-six RA patients and 200 healthy controls from Syria were 
      genotyped using polymerase chain reaction with sequence-specific primer 
      (PCR-SSP). Anti-CCP antibodies were measured by ELISA. Rheumatoid factor (RF), 
      C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and disease 
      activity score 28 (DAS-28) values were obtained from patients' medical records. 
      DAS-28 was used to assess the clinical severity of the patients. RESULTS: The 
      HLA-DRB1*01, *04, and *10 frequencies showed a strong association with the 
      disease susceptibility (OR = 2.29, 95% CI = 1.11-4.75, P = 0.022; OR = 3.16, 95% 
      CI = 2.0 -4.8, P < 0.0001; OR = 2.43, 95% CI = 1.07-5.51, P = 0.029 
      respectively), while the frequencies of HLA-DRB1*11, and *13 were significantly 
      lower in RA patients than in controls (OR = 0.49, 95% CI = 0.3-0.8, P = 0.004; OR 
      = 0.32, 95% CI = 0.15-0.69, P = 0.002, respectively). The other HLA-DRB1 alleles 
      showed no significant difference. The frequency of anti-CCP antibodies was higher 
      in shared epitope (SE) positive patients compared with SE-negative patients (OR = 
      5.5, 95% CI = 2-15.1, P = 0.00054). DAS-28 of RA patients didn't show significant 
      difference between the SE negative and the SE positive groups. CONCLUSION: Our 
      results indicate that HLA-DRB1*01, *04, and *10 alleles are related with RA, 
      while HLA-DRB1*11 and *13 protect against RA in the Syrian population.
FAU - Mourad, Jamil
AU  - Mourad J
AD  - School of Pharmacy, University of Damascus, Syria. jamilmourad@live.com
FAU - Monem, Fawza
AU  - Monem F
LA  - eng
LA  - por
PT  - Journal Article
PL  - Brazil
TA  - Rev Bras Reumatol
JT  - Revista brasileira de reumatologia
JID - 0404256
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Arthritis, Rheumatoid/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Severity of Illness Index
MH  - Syria
EDAT- 2013/04/17 06:00
MHDA- 2014/03/13 06:00
CRDT- 2013/04/17 06:00
PHST- 2011/12/08 00:00 [received]
PHST- 2012/12/13 00:00 [accepted]
PHST- 2013/04/17 06:00 [entrez]
PHST- 2013/04/17 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - S0482-5004(13)70057-3 [pii]
PST - ppublish
SO  - Rev Bras Reumatol. 2013 Feb;53(1):47-56.